Rabbit anti-Human C7orf49 Polyclonal Antibody | anti-CYREN antibody

Anti-C7orf49 Antibody, Rabbit Polyclonal

Cat. Num. AAA8109320

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: C7orf49; Polyclonal Antibody; Anti-C7orf49 Antibody; Rabbit Polyclonal; C7orf49/CYREN Antibody; Rabbit PAb; Antigen Affinity Purified; chromosome 7 open reading frame 49; Anti-MRI Antibody; anti-CYREN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human C7orf49/CYREN
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-CYREN antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:50-1:200
• Immunogen: E Coli-derived Human C7orf49/CYREN fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human C7orf49/CYREN fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human C7orf49 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human C7orf49 in human breast with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-CYREN antibody

CYREN (Cell cYcle REgulator of NHEJ) was originally identified as a potential modulator of retroviral infection. The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). MRI is intrinsically disordered and interacts with many DNA damage response (DDR) proteins, including the kinases ataxia telangiectasia mutated (ATM) and DNA-PKcs and the classical non-homologous end joining (cNHEJ) factors Ku70, Ku80, XRCC4, XLF, PAXX, and XRCC4. MRI forms large multimeric complexes that depend on its N and C termini and localizes to DNA double-strand breaks (DSBs), where it promotes the retention of DDR factors. Mice deficient in MRI and XLF exhibit embryonic lethality at a stage similar to those deficient in the core cNHEJ factors XRCC4 or DNA ligase IV. Moreover, MRI is required for cNHEJ-mediated DSB repair in XLF-deficient lymphocytes. MRI is an adaptor that, through multivalent interactions, increases the avidity of DDR factors to DSB-associated chromatin to promote cNHEJ.

References

Hung PJ, et al. (2018) Mri is a DNA damage response adaptor during classical non-homologous end joining. Mol Cell 71 (2): 332-342.e338.Arnoult N, et al. (2017) Regulation of DNA repair pathway choice in s and g2 phases by the nhej inhibitor cyren. Nature 549 (7673): 548-552.