Rabbit anti-Human C1R Polyclonal Antibody | anti-C1R antibody

C1R Polyclonal Antibody

Cat. Num. AAA2562400

• Gene Names: C1R; EDSPD1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: C1R; Polyclonal Antibody; C1R Polyclonal Antibody; C1 R; Complement C1r; Complement C1r subcomponent; Complement C1r subcomponent light chain; Complement C1r subcomponent precursor; Complement component 1 r subcomponent; Complement component 1 subcomponent r; anti-C1R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.6mg/mL (varies by lot)
• Sequence Length: 705

• Applicable Applications for anti-C1R antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:40-1:200; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human C1R
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Human plasma solution using C1R Polyclonal Antibody at dilution of 1:800)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using C1R Polyclonal Antibody at dilution of 1:40(×200))

Related Product Information for anti-C1R antibody

C1R (Complement C1r) is a Protein Coding gene. Diseases associated with C1R include Ehlers-Danlos Syndrome, Periodontal Type, 1 and Periodontal Ehlers-Danlos Syndrome. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is MASP2.

Product Categories/Family for anti-C1R antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 66347875
• NCBI GeneID: 715
• NCBI Accession #: NP_001724.3; BC035220
• NCBI GenBank Nucleotide #: NP_001724.3
• UniProt Accession #: P00736
• Molecular Weight: 80 kDa
• NCBI Official Full Name: complement C1r subcomponent
• NCBI Official Synonym Full Names: complement C1r
• NCBI Official Symbol: C1R
• NCBI Official Synonym Symbols: EDSPD1
• NCBI Protein Information: complement C1r subcomponent
• UniProt Protein Name: Complement C1r subcomponent
• Protein Family: Complement C1r subcomponent
• UniProt Gene Name: C1R
• UniProt Entry Name: C1R_HUMAN

NCBI Description

This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018]

Uniprot Description

C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.41; Protease

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1r/c1s Deficiency