Rabbit C1D Polyclonal Antibody | anti-C1D antibody

C1D Rabbit Polyclonal

Cat. Num. AAA767288

• Gene Names: C1D; LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: C1D; Polyclonal Antibody; C1D Rabbit Polyclonal; anti-C1D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 141

• Applicable Applications for anti-C1D antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: C1D nuclear receptor co-repressor
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using MBS767288 (C1D antibody) at dilution of 1:200)

NCBI and Uniprot Product Information

• NCBI GI #: 1185119
• NCBI GeneID: 10438
• UniProt Accession #: Q13901; Q05D64; A8K336; D6W5F8
• Molecular Weight: 16,019 Da
• NCBI Official Full Name: C1D protein
• NCBI Official Synonym Full Names: C1D nuclear receptor corepressor
• NCBI Official Symbol: C1D
• NCBI Official Synonym Symbols: LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
• NCBI Protein Information: nuclear nucleic acid-binding protein C1D
• UniProt Protein Name: Nuclear nucleic acid-binding protein C1D
• Protein Family: Nuclear nucleic acid-binding protein
• UniProt Gene Name: C1D
• UniProt Synonym Gene Names: hC1D
• UniProt Entry Name: C1D_HUMAN

NCBI Description

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Description

C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.

Protein type: Transcription, coactivator/corepressor; Nucleolus; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p13-p12

Cellular Component: cytoplasm; nuclear exosome (RNase complex); nucleolus; nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: DNA binding; ligand-dependent nuclear receptor binding; protein binding; RNA binding; transcription corepressor activity

Biological Process: apoptosis; maturation of 5.8S rRNA; negative regulation of transcription, DNA-dependent; rRNA processing; transcription, DNA-dependent