Rabbit anti-Human C10orf90 Polyclonal Antibody | anti-C10orf90 antibody

C10orf90 Antibody

Cat. Num. AAA9630479

• Gene Names: C10orf90; FATS; bA422P15.2
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: C10orf90; Polyclonal Antibody; C10orf90 Antibody; bA422P15.2; Chromosome 10 open reading frame 90; CJ090_HUMAN; D7Ertd443e; FATS; RP11-422P15.2; Uncharacterized protein C10orf90; anti-C10orf90 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: C10orf90 Antibody detects endogenous levels of C10orf90.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-C10orf90 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human C10orf90.
• Conjugation: Unconjugated
• Subunit Structure: Interacts with HDAC1; the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with p53/TP53; the interaction inhibits binding of p53/TP53 and MDM2.
• Function: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable).
• Note: Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-C10orf90 antibody

Cytoplasm; Cytoskeleton; Microtubule organizing center; Centrosome; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 52145312
• NCBI GeneID: 118611
• NCBI Accession #: NP_001004298.2
• NCBI GenBank Nucleotide #: NM_001004298.2
• UniProt Accession #: Q96M02; Q5JRP6; Q5T023; Q8NCV5; Q8WU75; B9EIQ9
• Molecular Weight: 67,103 Da
• NCBI Official Full Name: centrosomal protein C10orf90
• NCBI Official Synonym Full Names: chromosome 10 open reading frame 90
• NCBI Official Symbol: C10orf90
• NCBI Official Synonym Symbols: FATS; bA422P15.2
• NCBI Protein Information: centrosomal protein C10orf90
• UniProt Protein Name: Centrosomal protein C10orf90
• Protein Family: Centrosomal protein
• UniProt Gene Name: C10orf90
• UniProt Synonym Gene Names: FATS
• UniProt Entry Name: CJ090_HUMAN

Uniprot Description

C10orf90: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. May have a role in the assembly of primary cilia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: centrosome; cytoplasm; actin cytoskeleton

Molecular Function: histone deacetylase binding

Biological Process: protein stabilization; mitotic cell cycle G2/M transition DNA damage checkpoint; response to ionizing radiation; negative regulation of cell growth; response to UV