Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CTBP1 Polyclonal Antibody at dilution 1:30)
Rabbit CTBP1 Polyclonal Antibody | anti-CTBP1 antibody
CTBP1 Polyclonal Antibody
IHC: 1:25-100
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CTBP1 Polyclonal Antibody at dilution 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CTBP1 Polyclonal Antibody at dilution 1:30)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
CTBP1: Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)- specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: NAD binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; transcription factor binding
Biological Process: negative regulation of cell proliferation; negative regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone deacetylation; protein amino acid phosphorylation; regulation of cell cycle; viral genome replication; white fat cell differentiation
Disease: Wolf-hirschhorn Syndrome
Research Articles on CTBP1
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Product Notes
The CTBP1 ctbp1 (Catalog #AAA2543126) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTBP1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CTBP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:25-100. Researchers should empirically determine the suitability of the CTBP1 ctbp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTBP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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