Immunohistochemistry (IHC)
(Immunochemical staining of human BTG3 in human ovarian cancer with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
Rabbit BTG3 Polyclonal Antibody | anti-BTG3 antibody
Anti-BTG3 Antibody, Rabbit Polyclonal
Gene Names
BTG3; ANA; TOB5; TOFA; TOB55
Reactivity
HumanPredicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
BTG3; Polyclonal Antibody; Anti-BTG3 Antibody; Rabbit Polyclonal; BTG3 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-ANA Antibody; Anti-TOB5 Antibody; Anti-TOB55 Antibody; Anti-TOFA Antibody; anti-BTG3 antibody
Host
Rabbit
Reactivity
Human
Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human BTG3
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-BTG3 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:500
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human BTG3
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human BTG3, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human BTG3 in human ovarian cancer with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human BTG3 in human ovarian cancer with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-BTG3 antibody
B-cell translocation gene 3 (BTG3) has been identified as a candidate driver gene for various cancers. BTG3 expression might contribute to CRC carcinogenesis. BTG3 knockdown might strengthen the aggressive colorectal cancer behavior. BTG3 knockdown promoted cell proliferation, migration, invasion, relieved G2 arrest, and inhibited apoptosis in HCT116 and LoVo cells. BTG3 may be involved in the occurrence and development of tumor, and its low expression may be associated with poor prognosis in patients with PDAC. BTG3 overexpression could inhibit cell proliferation and invasion and promotes cell apoptosis in EOC cell, possibly by regulating the AKT/GSK3beta/beta-catenin signaling pathway, providing novel insights into the treatment of EOC through BTG3 overexpression. MiR-93 was decreased and BTG3 was increased in ESC cells, with a negative correlation of their expression in ESC tissues. Direct downregulation of BTG3 by miR-93 is able to render ESC resistant to radiotherapy, and both BTG3 and miR-93 may potentially serve as clinical markers for ESC and contribute to the treatment of ESC.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
29,116 Da
NCBI Official Full Name
BTG family, member 3, isoform CRA_a
NCBI Official Synonym Full Names
BTG family, member 3
NCBI Official Symbol
BTG3
NCBI Official Synonym Symbols
ANA; TOB5; TOFA; TOB55
NCBI Protein Information
protein BTG3; protein Tob5; B-cell translocation gene 3; abundant in neuroepithelium area protein
UniProt Protein Name
Protein BTG3
Protein Family
UniProt Gene Name
BTG3
UniProt Synonym Gene Names
ANA; TOB5
UniProt Entry Name
BTG3_HUMAN
NCBI Description
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Description
BTG3: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. Belongs to the BTG family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 21q21.1
Cellular Component: cytoplasm
Molecular Function: protein binding
Biological Process: negative regulation of cell proliferation; negative regulation of mitotic cell cycle
Research Articles on BTG3
Similar Products
Product Notes
The BTG3 btg3 (Catalog #AAA8102431) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-BTG3 Antibody, Rabbit Polyclonal reacts with Human Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology) and may cross-react with other species as described in the data sheet. AAA Biotech's BTG3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:500. Researchers should empirically determine the suitability of the BTG3 btg3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BTG3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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