Mouse anti-Human BST2 Polyclonal Antibody | anti-BST2 antibody

BST2 (Bone Marrow Stromal Antigen 2, BST-2, HM1.24 Antigen, Tetherin, CD317)

Cat. Num. AAA626908

• Gene Names: BST2; CD317; TETHERIN
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Purified; Purified.
• Synonyms: BST2; Polyclonal Antibody; BST2 (Bone Marrow Stromal Antigen 2; BST-2; HM1.24 Antigen; Tetherin; CD317); Anti -BST2 (Bone Marrow Stromal Antigen 2; anti-BST2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human BST2.
• Purity/Purification: Purified; Purified.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-BST2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry (paraffin), and Immunofluorescence.
• Immunogen: BST2 (NP_004326.1, 1-180aa) full-length human protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-BST2 antibody

Bone marrow stromal Antigen-2 (BST-2) is a 30-36kD type II transmembrane protein, consisting of 180aa. BST-2 protein is expressed on certain bone marrow stromal cell lines and on various normal tissues. The expression pattern of BST2 is relatively different form another bone marrow stromal antigen 1 (BST1). The BST-2 gene is located on chromosome 19p13.2. BST-2 surface expression on fibroblast cell lines facilitated the stromal cell-dependent growth of a murine bone marrow-derived pre-B-cell line, DW34. Some studies suggest that BST-2 may be involved in pre-B-cell growth development by regulating their surface molecules and cytokines. BST2 is also expressed in bone marrow stromal cell lines and synovial cell lines from where the BST2 gene was cloned. BST2 is predominantly expressed in liver, lungs, heart, placenta and lower levels in pancreas, kidney, skeletal muscle and brain.

Product Categories/Family for anti-BST2 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4757876
• NCBI GeneID: 684
• NCBI Accession #: NP_004326.1
• NCBI GenBank Nucleotide #: NM_004335.3
• UniProt Accession #: Q10589; Q53G07; A8K4Y4
• Molecular Weight: 19,769 Da
• NCBI Official Full Name: bone marrow stromal antigen 2
• NCBI Official Synonym Full Names: bone marrow stromal cell antigen 2
• NCBI Official Symbol: BST2
• NCBI Official Synonym Symbols: CD317; TETHERIN
• NCBI Protein Information: bone marrow stromal antigen 2; BST-2; NPC-A-7; HM1.24 antigen
• UniProt Protein Name: Bone marrow stromal antigen 2
• Protein Family: Bone marrow stromal antigen
• UniProt Gene Name: BST2
• UniProt Synonym Gene Names: BST-2
• UniProt Entry Name: BST2_HUMAN

NCBI Description

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Uniprot Description

BST2: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma- associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Belongs to the tetherin family.

Protein type: Membrane protein, integral; Membrane protein, GPI anchor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: Golgi apparatus; cell surface; membrane; integral to plasma membrane; cytoplasm; apical plasma membrane; late endosome; plasma membrane; lipid raft

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; signal transducer activity; protein homodimerization activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; B cell activation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; response to virus; humoral immune response; cell proliferation; negative regulation of plasmacytoid dendritic cell cytokine production; negative regulation of viral genome replication; cell-cell signaling; regulation of actin cytoskeleton organization and biogenesis; innate immune response; negative regulation of cell growth; negative regulation of cell migration; defense response to virus