Rabbit anti-Mouse, Rat BSG Polyclonal Antibody | anti-BSG antibody

BSG Polyclonal Antibody

Cat. Num. AAA2554129

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: BSG; Polyclonal Antibody; BSG Polyclonal Antibody; 5A11 antigen; 5F7; BASI; Basigin (Ok blood group); Basigin; Blood brain barrier HT7 antigen; Bsg; CD 147; CD147; CD147 antigen; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M 6; M6; M6 leukocyte activation antigen; Neurothelin; OK; OK blood group; OK blood group antigen; TCSF; Tumor cell derived collagenase stimulatory factor; Tumor cell-derived collagenase stimulatory factor; anti-BSG antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Concentration: 1 mg/mL (varies by lot)

• Applicable Applications for anti-BSG antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB 1:1000-1:2000; IHC 1:100-1:300
• Immunogen: Recombinant Mouse Basigin protein
• Conjugation: Unconjugated
• Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Rat liver and Rat heart using BSG Polyclonal Antibody at dilution of 1:1000)

Western Blot (WB)

(Western Blot analysis of Mouse kidney and Mouse liver using BSG Polyclonal Antibody at dilution of 1:1000)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse liver using BSG Polyclonal Antibody at dilution of 1:200)

Related Product Information for anti-BSG antibody

BSG,also named as 5F7,Basigin,EMMPRIN,TCSF and CD147,plays pivotal roles in spermatogenesis,embryo implantation,neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).CD147 may target monocarboxylate transporters SLC16A1,SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. It seems to be a receptor for oligomannosidic glycans. CD147 is a receptor of CypA,inducing matrix metalloproteinase expression and mediating the degradation of the extracellular matrix,plays an important role in tumorigenesis and invasion in oral cancer. It has been considered as an objective and effective marker to predict invasion and prognosis in various cancers.

Product Categories/Family for anti-BSG antibody

Cancer; Cardiovascular; Metabolism; Immunology; Neuroscience

NCBI and Uniprot Product Information

• UniProt Accession #: P18572
• Molecular Weight: 30 kDa,40-60 kDa
• Protein Family: Basigin

NCBI Description

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Uniprot Description

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.