CD147/BSG/Basigin Protein Recombinant Protein | CD147/BSG recombinant protein

Recombinant Rat CD147/BSG/Basigin Protein (His Tag)

Cat. Num. AAA2569432

• Gene Names: Bsg; CE9; HT7; 5A11; Ox47R; EMMPRIN; basignin
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: CD147/BSG/Basigin Protein; Recombinant Rat CD147/BSG/Basigin Protein (His Tag); 5A11 antigen; 5F7; BASI; Basigin (Ok blood group); Basigin; Blood brain barrier HT7 antigen; Bsg; CD 147; CD147; CD147 antigen; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M 6; M6; M6 leukocyte activation antigen; Neurothelin; OK; OK blood group; OK blood group antigen; TCSF; Tumor cell derived collagenase stimulatory factor; Tumor cell-derived collagenase stimulatory factor; CD147/BSG recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: Pro52-Thr324

• Species: Rat
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Rat BSG (P26453-1)(Pro52-Thr324) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for CD147/BSG recombinant protein

BSG,also named as 5F7,Basigin,EMMPRIN,TCSF and CD147,plays pivotal roles in spermatogenesis,embryo implantation,neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).CD147 may target monocarboxylate transporters SLC16A1,SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. It seems to be a receptor for oligomannosidic glycans. CD147 is a receptor of CypA,inducing matrix metalloproteinase expression and mediating the degradation of the extracellular matrix,plays an important role in tumorigenesis and invasion in oral cancer. It has been considered as an objective and effective marker to predict invasion and prognosis in various cancers.

NCBI and Uniprot Product Information

• NCBI GI #: 158081773
• NCBI GeneID: 25246
• NCBI Accession #: NP_001103352.1
• NCBI GenBank Nucleotide #: NM_001109882.1
• UniProt Accession #: P26453; Q7TNP1
• Molecular Weight: 29,585 Da
• NCBI Official Full Name: basigin isoform 1
• NCBI Official Synonym Full Names: basigin (Ok blood group)
• NCBI Official Symbol: Bsg
• NCBI Official Synonym Symbols: CE9; HT7; 5A11; Ox47R; EMMPRIN; basignin
• NCBI Protein Information: basigin; Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); OX-47 antigen; glycoprotein CE9
• UniProt Protein Name: Basigin
• UniProt Gene Name: Bsg
• UniProt Entry Name: BASI_RAT

NCBI Description

MRC OX-47 antigen that is upregulated on activated lymphocytes; member of the immunoglobulin superfamily [RGD, Feb 2006]

Uniprot Description

BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Cellular Component: focal adhesion; membrane; mitochondrion; integral to plasma membrane; melanosome; plasma membrane; sarcolemma; acrosomal membrane; lipid raft

Molecular Function: mannose binding; protein binding

Biological Process: response to mercury ion; response to peptide hormone stimulus; response to cAMP; decidualization; embryo implantation; odontogenesis of dentine-containing teeth