Rabbit BRD3 Polyclonal Antibody | anti-BRD3 antibody

BRD3 Rabbit Polyclonal

Cat. Num. AAA767179

• Gene Names: BRD3; ORFX; RING3L
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: BRD3; Polyclonal Antibody; BRD3 Rabbit Polyclonal; anti-BRD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 556

• Applicable Applications for anti-BRD3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Bromodomain containing 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor using MBS767179 (BRD3 antibody) at dilution of 1:50)

Testing Data

()

Western Blot (WB)

(human brain tissue were subjected to SDS PAGE followed by western blot with MBS767179 (BRD3 antibody) at dilution of 1:200)

NCBI and Uniprot Product Information

• NCBI GI #: 21594670
• NCBI GeneID: 8019
• Molecular Weight: 60,942 Da
• NCBI Official Full Name: BRD3 protein
• NCBI Official Synonym Full Names: bromodomain containing 3
• NCBI Official Symbol: BRD3
• NCBI Official Synonym Symbols: ORFX; RING3L
• NCBI Protein Information: bromodomain-containing protein 3
• UniProt Protein Name: Bromodomain-containing protein 3
• Protein Family: Bromodomain-containing protein
• UniProt Gene Name: BRD3
• UniProt Synonym Gene Names: KIAA0043; RING3L
• UniProt Entry Name: BRD3_HUMAN

NCBI Description

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

Uniprot Description

BRD3: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1 gene. A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BRD family

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: nucleus

Molecular Function: chromatin binding; protein binding

Biological Process: chromatin modification; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent