Rabbit BOULE Polyclonal Antibody | anti-BOLL antibody

BOULE Antibody

Cat. Num. AAA9629489

• Gene Names: BOLL; BOULE
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: BOULE; Polyclonal Antibody; BOULE Antibody; Bol (Drosophila boule homolog) like; Bol; Bol boule like; boule like (Drosophila); bol; boule-like (Drosophila); Boll; BOLL_HUMAN; Boule like; Drosophila; homolog of; Protein boule like; Protein boule-like; Putative uncharacterized protein BOLL; anti-BOLL antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: BOULE Antibody detects endogenous levels of total BOULE.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-BOLL antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the RRM DAZ family.
• Subunit Structure: Interacts with DAZ1 and DAZL.
• Tissue Specificity: Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.
• Function: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-BOLL antibody

Cytoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 547235468
• NCBI GeneID: 66037
• NCBI Accession #: NP_001271287.1
• NCBI GenBank Nucleotide #: NM_001284358.1
• UniProt Accession #: Q8N9W6; Q0JW32; Q53T62; Q969U3; B4DZA4
• Molecular Weight: 19,256 Da
• NCBI Official Full Name: protein boule-like isoform 3
• NCBI Official Synonym Full Names: boule-like RNA-binding protein
• NCBI Official Symbol: BOLL
• NCBI Official Synonym Symbols: BOULE
• NCBI Protein Information: protein boule-like; bol, boule-like
• UniProt Protein Name: Protein boule-like
• Protein Family: Protein boule
• UniProt Gene Name: BOLL
• UniProt Synonym Gene Names: BOULE
• UniProt Entry Name: BOLL_HUMAN

NCBI Description

This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BOLL: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Belongs to the RRM DAZ family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoplasm

Molecular Function: protein binding; translation activator activity; RNA binding; nucleotide binding

Biological Process: positive regulation of translational initiation; meiosis; multicellular organismal development; spermatogenesis; cell differentiation