Rabbit anti-Human Bone Morphogenetic Protein Receptor 2 (BMPR2) Polyclonal Antibody | anti-BMPR2 antibody
Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
Uniprot Description
BMPR2: a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure.
Protein type: Cell cycle regulation; EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 2q33.1-q33.2
Cellular Component: apical plasma membrane; basal plasma membrane; caveola; cell soma; cell surface; cell-cell adherens junction; cytoplasm; dendrite; extracellular space; integral component of plasma membrane; nucleoplasm; plasma membrane; postsynaptic density; spanning component of plasma membrane
Molecular Function: activin receptor activity, type II; ATP binding; BMP receptor activity; growth factor binding; metal ion binding; protein binding; signal transducer, downstream of receptor, with serine/threonine kinase activity
Biological Process: activin receptor signaling pathway; alveolus development; anterior/posterior pattern specification; atrioventricular valve morphogenesis; blood vessel remodeling; BMP signaling pathway; brain development; cardiac muscle tissue development; cellular response to BMP stimulus; cellular response to starvation; chondrocyte development; endocardial cushion development; endothelial cell apoptotic process; endothelial cell proliferation; limb development; lymphangiogenesis; maternal placenta development; mesoderm formation; mitral valve morphogenesis; negative regulation of cell growth; negative regulation of cell proliferation involved in heart valve morphogenesis; negative regulation of chondrocyte proliferation; negative regulation of DNA biosynthetic process; negative regulation of systemic arterial blood pressure; negative regulation of vasoconstriction; outflow tract morphogenesis; outflow tract septum morphogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of BMP signaling pathway; positive regulation of bone mineralization; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell migration; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; proteoglycan biosynthetic process; regulation of cell proliferation; regulation of lung blood pressure; semi-lunar valve development; transcription from RNA polymerase II promoter; transmembrane receptor protein serine/threonine kinase signaling pathway; tricuspid valve morphogenesis; vascular endothelial growth factor receptor signaling pathway
Disease: Pulmonary Hypertension, Primary, 1; Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Research Articles on BMPR2
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Product Notes
The BMPR2 bmpr2 (Catalog #AAA2091317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein Receptor 2 (BMPR2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Bone Morphogenetic Protein Receptor 2 (BMPR2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the BMPR2 bmpr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bone Morphogenetic Protein Receptor 2 (BMPR2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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