Rabbit anti-Human BMPRIB Polyclonal Antibody | anti-BMPR1B antibody

Anti-BMPRIB Antibody, Rabbit Polyclonal

Cat. Num. AAA8102881

• Gene Names: BMPR1B; ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: BMPRIB; Polyclonal Antibody; Anti-BMPRIB Antibody; Rabbit Polyclonal; ALK-6/BMPR1B Antibody; Rabbit PAb; Antigen Affinity Purified; bone morphogenetic protein receptor; type IB; Anti-ALK-6 Antibody; Anti-ALK6 Antibody; Anti-CDw293 Antibody; anti-BMPR1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human ALK-6/BMPR1B
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-BMPR1B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000; ELISA: 1:25,000-1:50,000
• Immunogen: Recombinant Human ALK-6/BMPR1B Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human ALK-6/BMPR1B (rh ALK-6/BMPR1B). ALK-6/BMPR1B specific IgG was purified by Human ALK-6/BMPR1B affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-ALK6(149-502) rabbit polyclonal antibody at 1:500 dilutionLane A: U87MG Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:57 kDaObserved band size:50 kDa(We are unsure as to the identity of these extra bands.))

Related Product Information for anti-BMPR1B antibody

BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective transducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

References

Ide H, et al. (1998) Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23--q24 byin situ hybridization and radiation hybrid map ping. Cytogenet. Cell Genet. 81(3-4): 285-6.Mishina Y, et al. (2004) Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 279(26): 27560-6.Yoon BS, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci. 102(14): 5062-7.

NCBI and Uniprot Product Information

• NCBI GI #: 4502431
• NCBI GeneID: 658
• NCBI Accession #: NP_001194.1
• NCBI GenBank Nucleotide #: NM_001203.2
• UniProt Accession #: O00238; P78366; B2R953; B4DSV1
• Molecular Weight: 60,582 Da
• NCBI Official Full Name: bone morphogenetic protein receptor type-1B isoform b
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor type 1B
• NCBI Official Symbol: BMPR1B
• NCBI Official Synonym Symbols: ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
• NCBI Protein Information: bone morphogenetic protein receptor type-1B
• UniProt Protein Name: Bone morphogenetic protein receptor type-1B
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: BMPR1B
• UniProt Synonym Gene Names: BMP type-1B receptor; BMPR-1B
• UniProt Entry Name: BMR1B_HUMAN

Uniprot Description

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; protein amino acid phosphorylation; limb morphogenesis; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; inflammatory response; positive regulation of cell differentiation; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies