Rabbit anti-Human, Mouse BMPR1B Polyclonal Antibody | anti-BMPR1B antibody

Anti-BMPR1B Antibody

Cat. Num. AAA419931

• Gene Names: BMPR1B; ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purification
• Synonyms: BMPR1B; Polyclonal Antibody; Anti-BMPR1B Antibody; anti-BMPR1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Western blot analysis of extracts of mouse brain cell lines, using BMPR1B antibody. Immunofluorescence analysis of MCF7 cell using BMPR1B antibody. Blue: DAPI for nuclear staining.
• Purity/Purification: Affinity Purification
• Form/Format: Liquid
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 502

• Applicable Applications for anti-BMPR1B antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500 - 1:2000; IHC: 1:50- 1:200; IF: 1:50- 1:200
• Immunogen: Recombinant protein of human BMPR1B
• Storage Buffer: PBS with 0.02% sodium azide,50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

Immunofluorescence (IF)

Related Product Information for anti-BMPR1B antibody

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 377823731
• NCBI GeneID: 658
• NCBI Accession #: NP_001243723.1
• NCBI GenBank Nucleotide #: NM_001256794.1
• Molecular Weight: 60,582 Da
• NCBI Official Full Name: bone morphogenetic protein receptor type-1B isoform b
• NCBI Official Synonym Full Names: bone morphogenetic protein receptor type 1B
• NCBI Official Symbol: BMPR1B
• NCBI Official Synonym Symbols: ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
• NCBI Protein Information: bone morphogenetic protein receptor type-1B
• UniProt Protein Name: Bone morphogenetic protein receptor type-1B
• Protein Family: Bone morphogenetic protein receptor
• UniProt Gene Name: BMPR1B
• UniProt Synonym Gene Names: BMP type-1B receptor; BMPR-1B

NCBI Description

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22.3

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; glycoprotein binding; protein binding; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity

Biological Process: BMP signaling pathway; chondrocyte development; eye development; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; skeletal development

Disease: Brachydactyly, Type A1, D; Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies