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Western Blot (WB) (Western Blot analysis of 293 cell lysates (2ug/lane) using MBS630873. in either nontransfected (Lane 1) or transiently transfected with the BMP11 gene (Lane 2) (Origene Technologies) BMP11 (arrow).)

Rabbit anti-Human BMP11 Polyclonal Antibody

BMP11, NT (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP-11, GDF11)

Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
BMP11; Polyclonal Antibody; NT (Growth/Differentiation Factor 11; GDF-11; Bone Morphogenetic Protein 11; BMP-11; GDF11); Anti -BMP11; anti-BMP11 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human GDF11.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Applicable Applications for anti-BMP11 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
Immunogen
Synthetic peptide selected from the N-terminal region of human GDF11 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of 293 cell lysates (2ug/lane) using MBS630873. in either nontransfected (Lane 1) or transiently transfected with the BMP11 gene (Lane 2) (Origene Technologies) BMP11 (arrow).)

Western Blot (WB) (Western Blot analysis of 293 cell lysates (2ug/lane) using MBS630873. in either nontransfected (Lane 1) or transiently transfected with the BMP11 gene (Lane 2) (Origene Technologies) BMP11 (arrow).)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human colon carcinoma tissue using MBS630873, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)

Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human colon carcinoma tissue using MBS630873, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)

Testing Data

Testing Data
Related Product Information for anti-BMP11 antibody
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Product Categories/Family for anti-BMP11 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI Official Full Name
bone morphogenetic protein 11

Uniprot Description

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; skeletal development; cell development; metanephros development; growth

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Product Notes

The BMP11 (Catalog #AAA630873) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMP11, NT (Growth/Differentiation Factor 11, GDF-11, Bone Morphogenetic Protein 11, BMP-11, GDF11) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BMP11 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Immunohistochemistry: 1:10-1:50. Researchers should empirically determine the suitability of the BMP11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMP11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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