Goat anti-Human BIRC6 Polyclonal Antibody | anti-BIRC6 antibody

BIRC6 (BRUCE, KIAA1289, Baculoviral IAP repeat-containing 6, Apollon)

Cat. Num. AAA621937

• Gene Names: BIRC6; BRUCE; APOLLON; FLJ13726; FLJ13786; KIAA1289
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: BIRC6; Polyclonal Antibody; BIRC6 (BRUCE; KIAA1289; Baculoviral IAP repeat-containing 6; Apollon); Anti -BIRC6 (BRUCE; anti-BIRC6 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes BIRC6.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-BIRC6 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:16000
• Immunogen: Synthetic peptide of BIRC6.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-BIRC6 antibody

BIRC6 is a member of a family of proteins that inhibit apoptosis, likely through interference with activation of ICE-like proteases. BIRC6 which contains a single BIR domain and a ubiquitin-conjugating enzyme domain, is expressed in multiple cancer cell lines. Brain cancer cell lines that overexpress BIRC6 demonstrate multi-drug resistanceimplying that BIRC6 may protect cancer cells from undergoing apoptosis and participate in tumorigenesis and drug resistance.

Product Categories/Family for anti-BIRC6 antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 119620852
• NCBI GeneID: 57448
• UniProt Accession #: Q9NR09; Q9ULD1; Q9H8B7; Q9H8D8
• Molecular Weight: 530,255 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing 6 (apollon), isoform CRA_e
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 6
• NCBI Official Symbol: BIRC6
• NCBI Official Synonym Symbols: BRUCE; APOLLON; FLJ13726; FLJ13786; KIAA1289
• NCBI Protein Information: baculoviral IAP repeat-containing protein 6; OTTHUMP00000197747; baculoviral IAP repeat-containing 6; ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 6
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC6
• UniProt Synonym Gene Names: KIAA1289
• UniProt Entry Name: BIRC6_HUMAN

NCBI Description

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq]

Uniprot Description

BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.

Protein type: EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2p22.3

Cellular Component: spindle pole; membrane; microtubule organizing center; trans-Golgi network; midbody; endosome

Molecular Function: protein binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ligase activity

Biological Process: mitosis; apoptosis; cell division; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; negative regulation of apoptosis; regulation of cell proliferation