Immunohistochemistry (IHC)
(Anti-BEST2 / Bestrophin-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit BEST2 / Bestrophin-2 Polyclonal Antibody | anti-BEST2 antibody
Rabbit Polyclonal to Human BEST2 / Bestrophin-2
Gene Names
BEST2; VMD2L1
Reactivity
Gibbon, Bovine, Gorilla, Hamster, Human, Monkey, Mouse, Pig, RatPredicted Reactivity: Bat, Dog, Rabbit (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
BEST2 / Bestrophin-2; Polyclonal Antibody; Rabbit Polyclonal to Human BEST2 / Bestrophin-2; Anti-BEST2 / Bestrophin-2 Antibody (Internal) IHC-plus; BEST2; Bestrophin-2; Bestrophin 2; Hbest2; VMD2-like gene 1; VMD2L1; Human BEST2; anti-BEST2 antibody
Host
Rabbit
Reactivity
Gibbon, Bovine, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rat
Predicted Reactivity: Bat, Dog, Rabbit (at least 90% immunogen sequence identity)
Predicted Reactivity: Bat, Dog, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human BEST2 / Bestrophin-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BEST3 (59%).
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
509
Applicable Applications for anti-BEST2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (2.5 - 5 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human BEST2 / Bestrophin-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Bovine, Pig (100%); Panda, Dog, Bat, Rabbit, Opossum (94%).
Immunogen Type
Synthetic peptide
Immunogen
BEST2 / Bestrophin-2 antibody was raised against synthetic 17 amino acid peptide from internal region of human BEST2 / Bestrophin-2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Bovine, Pig (100%); Panda, Dog, Bat, Rabbit, Opossum (94%); Marmoset (88%).
Antigen Modification
Internal
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Immunohistochemistry (IHC)
(Anti-BEST2 / Bestrophin-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-BEST2 / Bestrophin-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-BEST2 antibody
VMD2L1, a bestrophin, is an anion channel.
Product Categories/Family for anti-BEST2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,139 Da
NCBI Official Full Name
bestrophin-2
NCBI Official Synonym Full Names
bestrophin 2
NCBI Official Symbol
BEST2
NCBI Official Synonym Symbols
VMD2L1
NCBI Protein Information
bestrophin-2; VMD2-like gene 1; vitelliform macular dystrophy 2-like 1; vitelliform macular dystrophy 2-like protein 1
UniProt Protein Name
Bestrophin-2
Protein Family
UniProt Gene Name
BEST2
UniProt Synonym Gene Names
VMD2L1
UniProt Entry Name
BEST2_HUMAN
NCBI Description
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]
Uniprot Description
BEST2: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: plasma membrane; cilium
Molecular Function: chloride channel activity
Biological Process: membrane depolarization; sensory perception of smell
Research Articles on BEST2
1. BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells
Similar Products
Product Notes
The BEST2 best2 (Catalog #AAA242853) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human BEST2 / Bestrophin-2 reacts with Gibbon, Bovine, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rat Predicted Reactivity: Bat, Dog, Rabbit (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's BEST2 / Bestrophin-2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (2.5 - 5 ug/ml). Researchers should empirically determine the suitability of the BEST2 best2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BEST2 / Bestrophin-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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