Rabbit anti-Human BD3 Polyclonal Antibody | anti-Defb3 antibody
BD3 (beta Defensin-3, CTIP1) (HRP)
Gene Names
Defb3; BD-3; MGC129397
Reactivity
Human
Applications
Western Blot
Purity
PurifiedPurified IgG
Synonyms
BD3; Polyclonal Antibody; BD3 (beta Defensin-3; CTIP1) (HRP); Anti -BD3 (beta Defensin-3; anti-Defb3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes residues 23-33 (GIINTLQKYYC) of the 5 kD hBD-3.
Purity/Purification
Purified
Purified IgG
Purified IgG
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative and no stabilizing protein added. Conjugated to horseradish peroxidase (HRP).
Applicable Applications for anti-Defb3 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1:500-1:1000 (ECL)
Immunofluorescence: 1:100-1:200 (Suggested; not tested)
Dilution: Western Blot: 1:500-1:1000 (ECL)
Immunofluorescence: 1:100-1:200 (Suggested; not tested)
Immunogen
Synthetic peptide corresponding to residues 23-33 [GIINTLQKYYC] of hBD-3 protein. MW of Antigen: 5kD
Preparation and Storage
Store at 4 degree C. Do Not Freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Related Product Information for anti-Defb3 antibody
A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.
Product Categories/Family for anti-Defb3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
7,126 Da
NCBI Official Full Name
beta-defensin 3
NCBI Official Synonym Full Names
defensin beta 3
NCBI Official Symbol
Defb3
NCBI Official Synonym Symbols
BD-3; MGC129397
NCBI Protein Information
beta-defensin 3; OTTMUSP00000022575
UniProt Protein Name
Beta-defensin 3
Protein Family
UniProt Gene Name
Defb3
UniProt Synonym Gene Names
Bd3
UniProt Entry Name
DEFB3_MOUSE
Uniprot Description
Function: Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. Ref.1
Subcellular location: Secreted.
Tissue specificity: Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. Ref.1 Ref.3
Induction: By bacterial infection. Ref.1
Sequence similarities: Belongs to the beta-defensin family. LAP/TAP subfamily.
Research Articles on Defb3
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Product Notes
The Defb3 defb3 (Catalog #AAA619488) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BD3 (beta Defensin-3, CTIP1) (HRP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BD3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1:500-1:1000 (ECL) Immunofluorescence: 1:100-1:200 (Suggested; not tested). Researchers should empirically determine the suitability of the Defb3 defb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BD3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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