Rabbit Bcl-7a Polyclonal Antibody | anti-Bcl-7a antibody

Bcl-7a (N62) Polyclonal Antibody

Cat. Num. AAA3013898

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Bcl-7a; Polyclonal Antibody; Bcl-7a (N62) Polyclonal Antibody; B cell CLL/lymphoma 7; B cell CLL/lymphoma 7 protein family member A; B cell CLL/lymphoma 7A; B-cell CLL/lymphoma 7 protein family member A; BCL 7; BCL7; bcl7a; BCL7A; anti-Bcl-7a antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Bcl-7a (N62) polyclonal antibody detects endogenous levels of Bcl-7a protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 210

• Applicable Applications for anti-Bcl-7a antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 30-84 of Human Bcl-7a.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of BCL7A pAb at 1:500 dilutionLane1:The Fallopian tube tissue lysate of Rat (40ug) Lane2:The Embryo tissue lysate of Mouse (40ug) Lane3:PC12 whole cell lysate (40ug) Lane4:CT-26 whole cell lysate (40ug) Lane5:PC3 whole cell lysate (40ug) Lane6:A2780 whole cell lysate (40ug) Lane7:LOVO whole cell lysate (40ug))

Related Product Information for anti-Bcl-7a antibody

Bcl-7a (B-cell CLL/lymphoma 7 protein family member A) is a 210 amino acid protein that belongs to the Bcl-7 family. Chromosomal aberrations involving a disruption of the amino-terminus of Bcl-7a may be a cause of B-cell nonHodgkin lymphoma (BNHL). Bcl-7b and Bcl-7c proteins share 90% identity with the N-terminal 51 amino acids of Bcl-7a, suggesting that the three genes are members of an evolutionarily conserved gene family. Bcl-7 gene family may be involved in early development. The Bcl-7a protein interacts with a novel human Polycomb ring finger gene and exists as two alternatively spliced isoforms. Bcl-7a may play a role in GC reaction and/or B-cell lymphomagenesis. The Bcl-7a gene maps to human chromosome 12q24.31. Chromosome 12 encodes over 1, 100 genes and comprises approximately 4.5% of the human genome.

NCBI and Uniprot Product Information

• NCBI GI #: 67190736
• NCBI Accession #: NP_001019979.1
• NCBI GenBank Nucleotide #: NP_001019979.1
• UniProt Accession #: Q4VC05
• Molecular Weight: ~ 26kDa
• NCBI Official Full Name: B-cell CLL/lymphoma 7 protein family member A isoform b
• UniProt Protein Name: B-cell CLL/lymphoma 7 protein family member A
• UniProt Gene Name: BCL7A
• UniProt Entry Name: BCL7A_HUMAN

Uniprot Description

Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 12q24.13

Biological Process: negative regulation of transcription, DNA-dependent