Porcine anti-Human Bcl 2 Polyclonal Antibody | anti-Bcl2 antibody
Bcl 2, phosphorylated (Thr56) (B Cell Leukemia 2)
Purified
Purified
Dilution: ELISA: 1:2000-1:100,000, detects Thr56 phosphorylated Bcl 2 peptide coated at 100ng/well.
Optimal dilutions to be determined by researcher.
Bcl 2 belongs to a family of genetically related proteins that appear to regulate apoptosis or programmed cell death. Bcl 2 is encoded by a proto-oncogene (bcl-2) that is the mammalian homolog of ced-9, the C. elegans death suppressor gene. Overexpression of Bcl 2 appears to suppress apoptosis in a number of mammalian experimental systems. Recent evidence indicates that Bcl 2 binds to other family members and R-ras and influences antioxidant pathways in the cell. Bcl 2 is a 25kD protein that has extensive amino acid homology with Bax. It forms homodimers or heterodimers with Bax and the apoptotic activity depends on the balance of both molecules. The t(14;18) translocation, which is a hallmark of human follicular lymphoma, generally involves the immunoglobulin heavy chain gene on chromosome 14 and the bcl-2 gene on chromosome 18. This translocation results in overexpression of the bcl-2 gene product (Bcl 2), promoting cell survival by blocking programmed cell death induced by different apoptotic stimuli.
NCBI and Uniprot Product Information
NCBI Description
an anti-apoptotic protein; involved in inhibiting cell death in many different cell types [RGD]
Uniprot Description
Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.
Protein type: Apoptosis; Membrane protein, integral; Autophagy; Oncoprotein
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; cytosol; pore complex; mitochondrial outer membrane; membrane; cytoplasm; mitochondrial membrane; intracellular; nucleus; myelin sheath
Molecular Function: BH domain binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; channel activity; protein heterodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding; protein phosphatase binding
Biological Process: focal adhesion formation; positive regulation of catalytic activity; developmental growth; pigment granule organization and biogenesis; regulation of cell cycle; response to toxin; ear development; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of protein localization; negative regulation of ossification; oligodendrocyte differentiation; regulation of transmembrane transporter activity; negative regulation of neuron apoptosis; kidney development; T cell differentiation; response to drug; spleen development; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of gene expression; response to estrogen stimulus; response to heat; negative regulation of osteoblast proliferation; response to oxidative stress; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of pigmentation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to insulin stimulus; response to organic substance; negative regulation of cell proliferation; positive regulation of skeletal muscle fiber development; ureteric bud development; positive regulation of cell proliferation; negative regulation of cell migration; transmembrane transport; regulation of viral genome replication; response to nutrient; leukocyte homeostasis; response to aluminum ion; mesenchymal cell development; aging; response to inorganic substance; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; response to UV-B; cell proliferation; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; response to copper ion; pigmentation; ureteric bud branching; homeostasis of number of cells within a tissue; response to hypoxia; negative regulation of cell growth; brain development; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; response to organic cyclic substance; response to caffeine; post-embryonic development; regulation of apoptosis; cochlear nucleus development; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; response to folic acid; positive regulation of B cell proliferation; negative regulation of mitotic cell cycle; T cell homeostasis; response to electrical stimulus; cell growth; defense response to virus; response to corticosterone stimulus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; induction of apoptosis via death domain receptors; response to steroid hormone stimulus; B cell differentiation; gland morphogenesis; regulation of pigmentation during development; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; response to peptide hormone stimulus; regulation of protein heterodimerization activity; response to cAMP; behavioral fear response; melanin metabolic process; regulation of cell-matrix adhesion; apoptosis; negative regulation of retinal cell programmed cell death; pigmentation during development; cell morphogenesis; regulation of protein stability; protein amino acid dephosphorylation; apoptotic mitochondrial changes; ovarian follicle development; B cell homeostasis; positive regulation of melanocyte differentiation; regulation of catalytic activity; melanocyte differentiation; response to gamma radiation; hemopoiesis; negative regulation of cellular pH reduction; response to iron ion; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; regulation of programmed cell death; cellular calcium ion homeostasis; immune system development; neuron apoptosis; T cell lineage commitment; axonogenesis; response to hydrogen peroxide; response to cytokine stimulus; response to DNA damage stimulus; induction of apoptosis by oxidative stress; growth
Research Articles on Bcl2
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Product Notes
The Bcl2 bcl2 (Catalog #AAA623561) is an Antibody produced from Porcine and is intended for research purposes only. The product is available for immediate purchase. The Bcl 2, phosphorylated (Thr56) (B Cell Leukemia 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Bcl 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Dilution: ELISA: 1:2000-1:100,000, detects Thr56 phosphorylated Bcl 2 peptide coated at 100ng/well. Optimal dilutions to be determined by researcher. Researchers should empirically determine the suitability of the Bcl2 bcl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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