Rabbit anti-Human BCAS1 Polyclonal Antibody | anti-BCAS1 antibody

BCAS1, CT (Breast Carcinoma-amplified Sequence 1, Amplified and Overexpressed in Breast Cancer, Novel Amplified in Breast Cancer 1, AIBC1, NABC1)

Cat. Num. AAA646867

• Gene Names: BCAS1; AIBC1; NABC1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: BCAS1; Polyclonal Antibody; CT (Breast Carcinoma-amplified Sequence 1; Amplified and Overexpressed in Breast Cancer; Novel Amplified in Breast Cancer 1; AIBC1; NABC1); Anti -BCAS1; anti-BCAS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human BCAS1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-BCAS1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 16aa from human BCAS1 at C-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-BCAS1 antibody

A novel gene, Novel Amplified in Breast Cancer-1 (NABC1) is implicated in breast cancer development. Breast tumor lines that harbor amplification of the cancer-related amplicon 20q13.2 display high levels of the NABC1 protein compared to normal human fibroblasts or a breast cancer line that does not overexpress the NABC1 mRNA. Alternate namesinclude Breast carcinoma amplified sequence 1, AIBC1, Amplified and overexpressed in breast cancer, breast carcinoma amplified sequence 1, Novel amplified in breast cancer 1

Product Categories/Family for anti-BCAS1 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 191251777
• NCBI GeneID: 8537
• NCBI Accession #: NP_003648.2
• NCBI GenBank Nucleotide #: NM_003657.2
• UniProt Accession #: O75363; Q68CZ3; A0AVG5
• Molecular Weight: 61,709 Da
• NCBI Official Full Name: breast carcinoma-amplified sequence 1
• NCBI Official Synonym Full Names: breast carcinoma amplified sequence 1
• NCBI Official Symbol: BCAS1
• NCBI Official Synonym Symbols: AIBC1; NABC1
• NCBI Protein Information: breast carcinoma-amplified sequence 1; novel amplified in breast cancer 1; amplified and overexpressed in breast cancer
• UniProt Protein Name: Breast carcinoma-amplified sequence 1
• Protein Family: Breast carcinoma-amplified sequence
• UniProt Gene Name: BCAS1
• UniProt Synonym Gene Names: AIBC1; NABC1
• UniProt Entry Name: BCAS1_HUMAN

NCBI Description

This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Jul 2008]

Uniprot Description

Subunit structure: Homodimer. May interact with DYNLL1 and DYNLL2

By similarity. Ref.6

Subcellular location: Cytoplasm Ref.6.

Tissue specificity: Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. Ref.4 Ref.6