Rabbit anti-Human BAP3 Polyclonal Antibody | anti-BAIAP3 antibody

BAP3 Antibody

Cat. Num. AAA150235

• Gene Names: BAIAP3; BAP3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: BAP3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: BAP3; Polyclonal Antibody; BAP3 Antibody; KIAA0734; BAI1-associated protein 3; BAI-associated protein 3; anti-BAIAP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BAP3 is known to have two isoforms; this BAP3 antibody will recognize only isoform 2. Lower molecular weight bands may represent cleavage or degradation products.
• Purity/Purification: BAP3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1187

• Applicable Applications for anti-BAIAP3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: BAP3 antibody can be used for the detection of BAP3 by Western blot at 1 and 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: BAP3 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human BAP3.
• Buffer: BAP3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: BAP3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of BAP3 in SK-N-SH cell lysate with BAP3 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemical staining of human brain tissue using BAP3 antibody at 5 μg/mL.)

Related Product Information for anti-BAIAP3 antibody

BAP3 Antibody: BAP3 was initially identified through interaction in a yeast two-hybrid system with the brain-specific angiogenesis inhibitor 1, a p53-target gene that encodes a seven-span transmembrane protein member of the secretin receptor family. BAP3 is predominantly expressed in the brain and possess high homology with Munc13 and synaptotagmin, suggesting that BAP3 may play a role in regulating neurotransmitter release. Recent experiments have shown that BAP3 is induced in certain tumors such as desmoplastic small round cell tumor. Ectopic expression of BAP3 in tumor cells dramatically enhances growth in low serum conditions and colony formation in soft agar, suggesting that the regulated exocytotic pathway may play a role in cancer cell proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 3929917
• NCBI GeneID: 8938
• UniProt Accession #: O94812; O94839; A2A2B2; B2RCD7; B4DGS5; B4DIK3; B4DRK9; B4DRP1; E7EUB9; H3BUH8; H3BVI3; H7C2Q1
• Molecular Weight: 124,344 Da
• NCBI Official Full Name: BAI-associated protein 3
• NCBI Official Synonym Full Names: BAI1-associated protein 3
• NCBI Official Symbol: BAIAP3
• NCBI Official Synonym Symbols: BAP3
• NCBI Protein Information: BAI1-associated protein 3; BAI-associated protein 3
• UniProt Protein Name: BAI1-associated protein 3
• Protein Family: BAI1-associated protein
• UniProt Gene Name: BAIAP3
• UniProt Synonym Gene Names: KIAA0734; BAP3
• UniProt Entry Name: BAIP3_HUMAN

NCBI Description

This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

BAIAP3: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.3

Molecular Function: protein C-terminus binding

Biological Process: G-protein coupled receptor protein signaling pathway; neurotransmitter secretion