Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse B-Cell CLL/Lymphoma 3 Polyclonal Antibody | anti-Bcl3 antibody
Polyclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- PLMPIYSTP TMAPHFPLLN LPTHPYSMIC PMEHPLSADI AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL SLFKLGSREV DVHNNLRQTP LHLAVITTLP DMVRLLVTAG ASPMALDRHG QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA LHVAVNTGCQ EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
Uniprot Description
Bcl-3: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Protein type: Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation
Chromosomal Location of Human Ortholog: 7 A3|7 9.95 cM
Cellular Component: Bcl3/NF-kappaB2 complex; cytoplasm; cytosol; intracellular membrane-bound organelle; midbody; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: DNA binding; DNA binding transcription factor activity; protein binding; transcription factor binding
Biological Process: antimicrobial humoral response; cellular response to DNA damage stimulus; defense response to bacterium; defense response to protozoan; DNA damage response, signal transduction by p53 class mediator; extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; humoral immune response mediated by circulating immunoglobulin; I-kappaB kinase/NF-kappaB signaling; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; marginal zone B cell differentiation; negative regulation of apoptosis; negative regulation of interleukin-8 biosynthetic process; negative regulation of JAK-STAT cascade; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of interferon-gamma production; positive regulation of interleukin-10 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of translation; protein import into nucleus, translocation; regulation of apoptosis; regulation of transcription, DNA-templated; response to UV-C; response to virus; spleen development; T-helper 1 type immune response; T-helper 2 cell differentiation; transcription, DNA-dependent
Research Articles on Bcl3
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Product Notes
The Bcl3 bcl3 (Catalog #AAA2026362) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's B-Cell CLL/Lymphoma 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the Bcl3 bcl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- PLMPIYSTP TMAPHFPLLN LPTHPYSMIC PMEHPLSADI AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL SLFKLGSREV DVHNNLRQTP LHLAVITTLP DMVRLLVTAG ASPMALDRHG QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA LHVAVNTGCQ EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP. It is sometimes possible for the material contained within the vial of "B-Cell CLL/Lymphoma 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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