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Western Blot (WB) ((0. 03ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Goat AVPR1A Polyclonal Antibody | anti-AVPR1A antibody

Goat anti-AVPR1A Antibody

Gene Names
AVPR1A; V1aR; AVPR1; AVPR V1a
Reactivity
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Applications
ELISA, Western Blot
Purity
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Synonyms
AVPR1A; Polyclonal Antibody; Goat anti-AVPR1A Antibody; arginine vasopressin receptor 1A; AVPR1; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; antidiuretic hormone receptor 1A; vascular/hepatic-type arginine vasopressin receptor; AVPR1A antibody; arginine vasopressin receptor 1A antibody; AVPR1 antibody; SCCL vasopressin subtype 1a receptor antibody; V1-vascular vasopressin receptor AVPR1A antibody; V1a vasopressin receptor antibody; antidiuretic hormone receptor 1A antibody; vascular/hepatic-type arginine vasopressin receptor antibody; anti-AVPR1A antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Clonality
Polyclonal
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (varies by lot)
Sequence
CHPLKTLQQPARRSR
Sequence Length
418
Applicable Applications for anti-AVPR1A antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 85kDa band observed in Human Brain (Frontal cortex) lysates and in Rat Brain lysates and in lysates of cell line NIH3T3 (calculated MW of 46.8kDa according to NP_000697.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Phalipou et al, J Biol Chem.1997 Oct 17;272(42): 26536-44; PMID: 9334232). Recommended concentration: 0. 03-0.1ug/ml.
Immunogen
Peptide with sequence CHPLKTLQQPARRSR, from the internal region of the protein sequence according to NP_000697.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.

Western Blot (WB)

((0. 03ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Western Blot (WB) ((0. 03ug/ml) staining of NIH3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
552
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,800 Da
NCBI Official Full Name
vasopressin V1a receptor
NCBI Official Synonym Full Names
arginine vasopressin receptor 1A
NCBI Official Symbol
AVPR1A
NCBI Official Synonym Symbols
V1aR; AVPR1; AVPR V1a
NCBI Protein Information
vasopressin V1a receptor
UniProt Protein Name
Vasopressin V1a receptor
Protein Family
UniProt Gene Name
AVPR1A
UniProt Synonym Gene Names
AVPR1; V1aR
UniProt Entry Name
V1AR_HUMAN

NCBI Description

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

Uniprot Description

AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q14-q15

Cellular Component: cytoplasmic vesicle; cytosol; endosome; integral to plasma membrane; plasma membrane

Molecular Function: peptide binding; peptide hormone binding; protein binding; protein kinase C binding; V1A vasopressin receptor binding; vasopressin receptor activity

Biological Process: blood circulation; calcium-mediated signaling; cellular response to hormone stimulus; cellular response to water deprivation; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; generation of precursor metabolites and energy; grooming behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; phospholipase C activation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone stimulus; social behavior; sperm ejaculation; telencephalon development

Research Articles on AVPR1A

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Product Notes

The AVPR1A avpr1a (Catalog #AAA421528) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-AVPR1A Antibody reacts with Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's AVPR1A can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 85kDa band observed in Human Brain (Frontal cortex) lysates and in Rat Brain lysates and in lysates of cell line NIH3T3 (calculated MW of 46.8kDa according to NP_000697.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Phalipou et al, J Biol Chem.1997 Oct 17;272(42): 26536-44; PMID: 9334232). Recommended concentration: 0. 03-0.1ug/ml. Researchers should empirically determine the suitability of the AVPR1A avpr1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: CHPLKTLQQP ARRSR. It is sometimes possible for the material contained within the vial of "AVPR1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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