Rabbit anti-Human Aven Polyclonal Antibody | anti-Aven antibody

Aven, CT

Cat. Num. AAA6007915

• Gene Names: Aven; CG15727; dAven; DmelCG15727
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Aven; Polyclonal Antibody; CT; Anti -Aven; anti-Aven antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Aven.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-Aven antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-1ug/ml. See A4445-10A for control peptide.; Immunohistochemistry: 5ug/ml
• Immunogen: 14 amino acid peptide from near the carboxy terminus of human Aven (GenBank accession no. NP_065104)
• Positive Control: Raji cell lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1ug/ml in (A) the presence and (B) the absence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5ug/ml.)

Related Product Information for anti-Aven antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a vari ety of diseases such as cancer (reviewed in 1). Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9 (2). It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients (3). Despite its predicted molecular weight, Aven often migrates at 55kD in SDS-PAGE.

Product Categories/Family for anti-Aven antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 18859763
• NCBI GeneID: 32215
• NCBI Accession #: NP_572817.1
• NCBI GenBank Nucleotide #: NM_132589.2
• UniProt Accession #: Q9VYK8
• Molecular Weight: 31,828 Da
• NCBI Official Full Name: aven ortholog
• NCBI Official Synonym Full Names: Aven ortholog
• NCBI Official Symbol: Aven
• NCBI Official Synonym Symbols: CG15727; dAven; DmelCG15727
• NCBI Protein Information: CG15727 gene product from transcript CG15727-RA; Aven-PA; CG15727-PA; aven ortholog
• UniProt Protein Name: Aven ortholog
• Protein Family: Avenin
• UniProt Gene Name: Aven
• UniProt Entry Name: Q9VYK8_DROME