Testing Data
(Gel: 10%SDS-PAGE Lysate: 40 ug Jurkat cell lysate Primary antibody: 1/400 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/5000 dilution Exposure time: 50 seconds)
Rabbit anti-Human, Mouse AVEN Polyclonal Antibody | anti-AVEN antibody
AVEN Antibody
Gene Names
AVEN; PDCD12
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Synonyms
AVEN; Polyclonal Antibody; AVEN Antibody; Apoptosis; caspase activation inhibitor; PDCD12; anti-AVEN antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total AVEN protein.
Form/Format
Supplied at 0.8mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Sequence Length
362
Applicable Applications for anti-AVEN antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: 1:500-1:5000
Western blotting: 1:500-1:1000
Western blotting: 1:500-1:1000
Immunogen Type
Peptide-KLH
Immunogen Description
Synthetic peptide corresponding to a region derived from 339-353 amino acids of Human Apoptosis, caspase activation inhibitor
Target Name
AVEN
Preparation and Storage
Store at -20 degree C/1 year
Testing Data
(Gel: 10%SDS-PAGE Lysate: 40 ug Jurkat cell lysate Primary antibody: 1/400 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/5000 dilution Exposure time: 50 seconds)
Testing Data
(Gel: 10%SDS-PAGE Lysate: 40 ug Jurkat cell lysate Primary antibody: 1/400 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/5000 dilution Exposure time: 50 seconds)
Related Product Information for anti-AVEN antibody
Aven binds to both Bcl-x(L) and the caspase regulator Apaf-1,which can supported that Bcl-x(L) inhibits cell death at a late (postmitochondrial) step in the death pathway.Identified in a yeast two-hybrid screen,Aven inhibited the proteolytic activation of caspases in a cell-free extract and suppressed apoptosis induced by Apaf-1 plus caspase-9. Expressing highly in the testis, ovary, and thymus.
Product Categories/Family for anti-AVEN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,506 Da
NCBI Official Full Name
cell death regulator Aven
NCBI Official Synonym Full Names
apoptosis, caspase activation inhibitor
NCBI Official Symbol
AVEN
NCBI Official Synonym Symbols
PDCD12
NCBI Protein Information
cell death regulator Aven
UniProt Protein Name
Cell death regulator Aven
Protein Family
UniProt Gene Name
AVEN
UniProt Entry Name
AVEN_HUMAN
Uniprot Description
AVEN: Protects against apoptosis mediated by Apaf-1. Binds Apaf-1, BCL-2 and BAD (Bcl-xl). Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.
Protein type: Inhibitor; Apoptosis
Chromosomal Location of Human Ortholog: 15q13.1
Cellular Component: membrane; endomembrane system; intracellular
Molecular Function: protein binding
Biological Process: apoptosis; negative regulation of apoptosis
Research Articles on AVEN
Similar Products
Product Notes
The AVEN aven (Catalog #AAA9407339) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AVEN Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AVEN can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:500-1:5000 Western blotting: 1:500-1:1000. Researchers should empirically determine the suitability of the AVEN aven for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AVEN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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