Immunohistochemistry (IHC)
(IHC on rat trigeminal nerve (free floating cryo section) using MBS618888 at a dilution of 1: 2000.)
Rabbit anti-Rat ATPase Type 13A2 Polyclonal Antibody | anti-ATP13A2 antibody
ATPase Type 13A2 (ATP13A2, Probable Cation-transporting ATPase 13A2)
Serum
Serum
Immunohistochemistry (IHC)
(IHC on rat trigeminal nerve (free floating cryo section) using MBS618888 at a dilution of 1: 2000.)
Immunohistochemistry (IHC)
(IHC on rat trigeminal nerve (free floating cryo section) using MBS618888 at a dilution of 1: 2000.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.
Uniprot Description
ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Transporter; Membrane protein, multi-pass; EC 3.6.3.-; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: lysosome; lysosomal membrane; integral to membrane
Molecular Function: protein binding; metal ion binding; ATPase activity; ATP binding
Biological Process: metabolic process; cation transport
Disease: Kufor-rakeb Syndrome
Research Articles on ATP13A2
2. ATP13A2 G2236A variant is rare in early-onset Parkinson's disease and familial Parkinson's disease patients from mainland China, which differs from the study in ethnic Chinese patients from Taiwan and Singapore
3. Research studied the prevalence of mutations in ATP13A2 genes in 30 unrelated Chinese families with AREP and found no pathogenic mutations.
4. Our data suggest that two mutated ATP13A2 alleles are not a common cause of Parkinson's disease
5. ATP13A2 gene mutations are rare in Chinese patients with familial autosomal recessive early-onset parkinsonism.
6. This study found that no associations were seen for ATP13A2 in Australia patient with Parkinson's disease
7. Neither ATP13A2 genetic variability nor quantitative gene expression in brain appears to contribute to familial parkinsonism or nonfamilial PD.
8. Mutations in ATP13A2 gene may be rare in Chinese families with autosomal recessive early-onset Parkinsonism.
9. A rare variant(AL746Thr) of the ATP13A2 was associated with an increased risk of Parkinson disease among ethnic Chinese in Asia. Further studies are needed to clarify the functional role of this genetic risk factor.
10. Observational study of gene-disease association. (HuGE Navigator)
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Product Notes
The ATP13A2 atp13a2 (Catalog #AAA618888) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATPase Type 13A2 (ATP13A2, Probable Cation-transporting ATPase 13A2) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATPase Type 13A2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Researchers should empirically determine the suitability of the ATP13A2 atp13a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATPase Type 13A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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