Rabbit anti-Human ATP1A3 Polyclonal Antibody | anti-ATP1A3 antibody

ATP1A3 Antibody, FITC conjugated

Cat. Num. AAA7049717

• Gene Names: ATP1A3; RDP; AHC2; CAPOS; DYT12; ATP1A1
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: ATP1A3; Polyclonal Antibody; ATP1A3 Antibody; FITC conjugated; Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+)ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3; anti-ATP1A3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 1024

• Applicable Applications for anti-ATP1A3 antibody: ELISA (EIA)
• Immunogen: Recombinant Human Sodium/potassium-transporting ATPase subunit alpha-3 protein (143-278AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Conjugation: FITC
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-134969 / sc-16052 / sc-67697
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-ATP1A3 antibody

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

NCBI and Uniprot Product Information

• NCBI GI #: 371940938
• NCBI GeneID: 478
• NCBI Accession #: NP_001243142.1
• NCBI GenBank Nucleotide #: NM_001256213.1
• UniProt Accession #: P13637; Q16732; Q16735; Q969K5; B7Z2T0; B7Z401; F5H6J6
• Molecular Weight: 113,059 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit alpha-3 isoform 2
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit alpha 3
• NCBI Official Symbol: ATP1A3
• NCBI Official Synonym Symbols: RDP; AHC2; CAPOS; DYT12; ATP1A1
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-3
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: ATP1A3
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-3 subunit
• UniProt Entry Name: AT1A3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: EC 3.6.3.9; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 19q13.31

Cellular Component: endoplasmic reticulum; Golgi apparatus; plasma membrane; sodium:potassium-exchanging ATPase complex; synapse

Molecular Function: chaperone binding; sodium:potassium-exchanging ATPase activity

Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import

Disease: Alternating Hemiplegia Of Childhood 2; Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss; Dystonia 12