Rabbit ATP1A1 Polyclonal Antibody | anti-ATP1A1 antibody

Anti-ATP1A1 Antibody (Internal)

Cat. Num. AAA2401659

• Reactivity: Human; Predicted: Mouse, Dog, Sheep, Bovine, Rat, Pig
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ATP1A1; Polyclonal Antibody; Anti-ATP1A1 Antibody (Internal); Mouse Monoclonal [clone 464.6 (6H)] (IgG1; k) to Rabbit ATP1A1; Na+; K+ ATPase alpha subunit; Na; K-ATPase alpha-1 subunit; Na+/K+ ATPase 1; Sodium pump 1; Sodium pump subunit alpha-1; anti-ATP1A1 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse, Dog, Sheep, Bovine, Rat, Pig
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of ATP1A1 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
• Sequence Length: 1023

• Applicable Applications for anti-ATP1A1 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 1:100; WB: 1:500-1:1000
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the central region of human ATP1A1.
• Conjugation: Unconjugated
• Epitope: Internal
• Preparation and Storage: Store at -20 degree C.; Aliquot to avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of ATP1A1 expression in HEK293T (A); HeLa (B) whole cell lysates.)

Related Product Information for anti-ATP1A1 antibody

ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integralmembrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane.These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle.

Product Categories/Family for anti-ATP1A1 antibody

Transporter; ATPase - P type; type IIC

NCBI and Uniprot Product Information

• NCBI GI #: 21361181
• NCBI GeneID: 476
• NCBI Accession #: NP_000692.2
• NCBI GenBank Nucleotide #: NM_000701.7
• UniProt Accession #: P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21; B2RBR6; B7Z2T5; B7Z3U6; F5H3A1
• Molecular Weight: 113,000 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit alpha-1 isoform a
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit alpha 1
• NCBI Official Symbol: ATP1A1
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-1
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-1
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: ATP1A1
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-1 subunit

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Description

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.