Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM antibody (Ser1981))
Rabbit anti-Mouse ATM Polyclonal Antibody | anti-ATM antibody
ATM Antibody (Ser1981)
Gene Names
ATM; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Reactivity
Mouse
Applications
Immunohistochemistry
Purity
Affinity Chromatography
Synonyms
ATM; Polyclonal Antibody; ATM Antibody (Ser1981); Rabbit Polyclonal ATM Antibody (Ser1981); Polyclonal ATM antibody; Anti-ATM antibody; A-T mutated antibody; Ataxia telangiectasia mutated antibody; Ataxia telangiectasia mutated homolog antibody; Serine-protein kinase ATM antibody; kinase ATM antibody; anti-ATM antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
ATM antibody (Ser1981) detects endogenous levels of ATM only when phosphorylated at serine 1981. The antibody will detect species specific phosphorylation as follows: Human: Ser1981, Mouse: Ser1987
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
Concentration
1 mg/ml (varies by lot)
Sequence Length
3056
Applicable Applications for anti-ATM antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:100
Immunogen
ATM antibody was raised in Rabbit using a synthesized phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S) as the immunogen.
Cross-Reactivity
Mouse
Preparation and Storage
Store at -20 degree C in small aliquots. Avoid repeat freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM antibody (Ser1981))
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM antibody (Ser1981))
Related Product Information for anti-ATM antibody
ATM regulates cell cycle checkpoints and DNA repair.
Product Categories/Family for anti-ATM antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
ATM
NCBI Official Synonym Full Names
ATM serine/threonine kinase
NCBI Official Symbol
ATM
NCBI Official Synonym Symbols
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
NCBI Protein Information
serine-protein kinase ATM
Protein Family
NCBI Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Research Articles on ATM
Similar Products
Product Notes
The ATM (Catalog #AAA5313565) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATM Antibody (Ser1981) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ATM can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:100. Researchers should empirically determine the suitability of the ATM for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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