Rabbit anti-Human ATL1 Polyclonal Antibody | anti-ATL1 antibody

ATL1, CT (ATL1, GBP3, SPG3A, Atlastin-1, Brain-specific GTP-binding protein, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A)

Cat. Num. AAA648329

• Gene Names: ATL1; FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ATL1; Polyclonal Antibody; CT (ATL1; GBP3; SPG3A; Atlastin-1; Brain-specific GTP-binding protein; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Spastic paraplegia 3 protein A); Anti -ATL1; anti-ATL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-ATL1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human ATL1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ATL1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATL1 antibody detected the ATL1 protein (arrow).)

Related Product Information for anti-ATL1 antibody

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

Product Categories/Family for anti-ATL1 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 189181742
• NCBI GeneID: 51062
• NCBI Accession #: NP_001121185.1
• NCBI GenBank Nucleotide #: NM_001127713.1
• UniProt Accession #: Q8WXF7; O95890; Q69YH7; Q96FK0; A6NND5; A8K2C0; G5E9T1
• Molecular Weight: 63,544 Da
• NCBI Official Full Name: atlastin-1 isoform b
• NCBI Official Synonym Full Names: atlastin GTPase 1
• NCBI Official Symbol: ATL1
• NCBI Official Synonym Symbols: FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1
• NCBI Protein Information: atlastin-1; GBP-3; hGBP3; GTP-binding protein 3; guanylate-binding protein 3; spastic paraplegia 3 protein A; brain-specific GTP-binding protein; guanine nucleotide-binding protein 3
• UniProt Protein Name: Atlastin-1
• Protein Family: Atlastin
• UniProt Gene Name: ATL1
• UniProt Synonym Gene Names: GBP3; SPG3A; GBP-3; hGBP3
• UniProt Entry Name: ATLA1_HUMAN

NCBI Description

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Ref.9 Ref.12 Ref.13 Ref.15

Subunit structure: Homooligomer. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 and RTN4 (via the transmembrane region). Interacts with SPAST; interaction is direct. May interact with TMED2. Interacts with REEP1. Ref.2 Ref.9 Ref.10 Ref.11 Ref.12 Ref.15 Ref.16

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection › axon

By similarity Ref.9 Ref.10 Ref.12 Ref.15.

Tissue specificity: Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). Ref.9 Ref.12 Ref.13

Involvement in disease: Spastic paraplegia 3, autosomal dominant (SPG3) [MIM:182600]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.12 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.25Hereditary sensory neuropathy 1D (HSN1D) [MIM:613708]: A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.24

Sequence similarities: Belongs to the GBP family. Atlastin subfamily.

Sequence caution: The sequence AAD20047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAK51160.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.