Rabbit anti-Human ATF7 Polyclonal Antibody | anti-ATF7 antibody

ATF7 Antibody - middle region

Cat. Num. AAA3223328

• Gene Names: ATF7; ATFA
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: ATF7; Polyclonal Antibody; ATF7 Antibody - middle region; anti-ATF7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Sequence: Synthetic peptide located within the following region: QILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNR
• Sequence Length: 494

• Applicable Applications for anti-ATF7 antibody: Western Blot (WB)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATF7
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: ATF7Sample Tissue: Human THP-1 Whole Cell lysatesAntibody Dilution: 1ug/ml)

Related Product Information for anti-ATF7 antibody

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Product Categories/Family for anti-ATF7 antibody

Polyclonal; Transcription Regulation; Signaling Intermediate

NCBI and Uniprot Product Information

• NCBI GI #: 194239643
• NCBI GeneID: 11016
• NCBI Accession #: NP_001123532.1
• NCBI GenBank Nucleotide #: NM_001130060.1
• UniProt Accession #: P17544
• Molecular Weight: 54 kDa
• NCBI Official Full Name: cyclic AMP-dependent transcription factor ATF-7 isoform 3
• NCBI Official Synonym Full Names: activating transcription factor 7
• NCBI Official Symbol: ATF7
• NCBI Official Synonym Symbols: ATFA
• NCBI Protein Information: cyclic AMP-dependent transcription factor ATF-7
• UniProt Protein Name: Cyclic AMP-dependent transcription factor ATF-7
• Protein Family: Cyclic AMP-dependent transcription factor
• UniProt Gene Name: ATF7
• UniProt Synonym Gene Names: ATFA; cAMP-dependent transcription factor ATF-7
• UniProt Entry Name: ATF7_HUMAN

Uniprot Description

ATF7: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Belongs to the bZIP family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding; sequence-specific DNA binding; metal ion binding; mitogen-activated protein kinase binding; transcription factor binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; viral reproduction; negative regulation of transcription from RNA polymerase II promoter