Rabbit anti-Human, Mouse ATF6B Polyclonal Antibody | anti-ATF6B antibody

ATF6B Antibody

Cat. Num. AAA9630860

• Gene Names: ATF6B; G13; CREBL1; CREB-RP
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ATF6B; Polyclonal Antibody; ATF6B Antibody; Activating transcription factor 6 beta; ATF 6 beta; ATF6-beta; ATF6B_HUMAN; ATF6beta; cAMP response element binding protein related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; CREB L1; Creb related protein; CREB RP; Creb-rp; CREBL 1; CREBL1; Crebrp; Cyclic AMP dependent transcription factor ATF 6 beta; Cyclic AMP dependent transcription factor ATF6 beta; FLJ10066; G13; G13 protein; OTTHUMP00000029432; OTTHUMP00000029433; Processed cyclic AMP-dependent transcription factor ATF-6 beta; Protein G13; anti-ATF6B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ATF6B Antibody detects endogenous levels of ATF6B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ATF6B antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ATF6B.
• Conjugation: Unconjugated
• Similarity: The basic domain functions as a nuclear localization signal. The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. Belongs to the bZIP family. ATF subfamily.
• Post Translational Modifications: N-glycosylated.During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
• Subunit Structure: Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).
• Tissue Specificity: Ubiquitous.
• Function: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
• Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ATF6B antibody

Endoplasmic reticulum membrane; Single-pass type II membrane protein; Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 209954788
• NCBI GeneID: 1388
• NCBI Accession #: NP_001129625.1
• NCBI GenBank Nucleotide #: NM_001136153.1
• UniProt Accession #: Q99941; Q13269; Q14343; Q14345; Q5SSW7; Q99635; Q99637; Q9H3V9; Q9H3W1; Q9NPL0; B0UYX6
• Molecular Weight: 76,709 Da
• NCBI Official Full Name: cyclic AMP-dependent transcription factor ATF-6 beta isoform b
• NCBI Official Synonym Full Names: activating transcription factor 6 beta
• NCBI Official Symbol: ATF6B
• NCBI Official Synonym Symbols: G13; CREBL1; CREB-RP
• NCBI Protein Information: cyclic AMP-dependent transcription factor ATF-6 beta; ATF6-beta; protein G13; Creb-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; cAMP respon
• UniProt Protein Name: Cyclic AMP-dependent transcription factor ATF-6 beta
• Protein Family: Cyclic AMP-dependent transcription factor
• UniProt Gene Name: ATF6B
• UniProt Synonym Gene Names: CREBL1; G13; cAMP-dependent transcription factor ATF-6 beta; ATF6-beta; Creb-rp
• UniProt Entry Name: ATF6B_HUMAN

NCBI Description

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Description

ATF6B: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; intracellular; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription, DNA-dependent; unfolded protein response; signal transduction