Western Blot (WB)
(Western Blot analysis of ATF6B in Mouse liver tissue,Hela cell,Human testis tissue,Jurkat and HEPG2 cell lysates in order using ATF6B Rabbit pAb at dilution 1/300)
Rabbit anti-Human, Mouse ATF6B Polyclonal Antibody | anti-ATF6B antibody
ATF6B Rabbit pAb
IHC-P: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of ATF6B in Mouse liver tissue,Hela cell,Human testis tissue,Jurkat and HEPG2 cell lysates in order using ATF6B Rabbit pAb at dilution 1/300)
Western Blot (WB)
(Western Blot analysis of ATF6B in Mouse liver tissue,Hela cell,Human testis tissue,Jurkat and HEPG2 cell lysates in order using ATF6B Rabbit pAb at dilution 1/300)
Immunohistochemistry (IHC)
(Immunohistochemistry of ATF6B in paraffin-embedded Human colorectal cancer tissue using ATF6B Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm and Nucleus)
Immunohistochemistry (IHC)
(Immunohistochemistry of ATF6B in paraffin-embedded Human colorectal cancer tissue using ATF6B Rabbit pAb at dilution 1/30. Predicted cell location: Cytoplasm and Nucleus)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Description
ATF6B: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; intracellular; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription, DNA-dependent; unfolded protein response; signal transduction
Research Articles on ATF6B
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Product Notes
The ATF6B atf6b (Catalog #AAA4759058) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATF6B Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ATF6B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the ATF6B atf6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATF6B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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