Rabbit ASZ1 Polyclonal Antibody | anti-ASZ1 antibody

ASZ1 Polyclonal Antibody

Cat. Num. AAA3005625

• Gene Names: ASZ1; ALP1; GASZ; Orf3; ANKL1; C7orf7; CT1.19
• Reactivity: Human, Mouse, Rat, Horse
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: ASZ1; Polyclonal Antibody; ASZ1 Polyclonal Antibody; Ankyrin repeat; SAM and basic leucine zipper domain containing protein 1; ALP1; ANKL1; Ankyrin like protein 1; ASZ 1; ASZ1_HUMAN.; anti-ASZ1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Horse
• Clonality: Polyclonal
• Specificity: ASZ1 Polyclonal Antibody detects endogenous levels of ASZ1 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-ASZ1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human ASZ1:151-250/475
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti-ASZ1 at 1/1000 dilution)

Related Product Information for anti-ASZ1 antibody

ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1), also known as ANKL1, ALP1 (Ankyrin-like protein 1), GASZ (germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) or Orf3, is a 475 amino acid protein that is suggested to function as a signal transducer during germ cell maturation. Localized to the cytoplasm of pachytene spermatocytes, early spermatids and oocytes, ASZ1 is primarily found in adult testis and ovary where it mediates protein-protein interactions. ASZ1 contains six ANK repeats, one SAM (sterile alpha motif) domain and is encoded by a gene located on human chromosome 7q31, a region that may have an important role in the development certain types of human cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 219519054
• NCBI GeneID: 136991
• UniProt Accession #: Q8WWH4; A0AV27; A4D0V0
• Molecular Weight: 53,458 Da
• NCBI Official Full Name: ASZ1 protein
• NCBI Official Synonym Full Names: ankyrin repeat, SAM and basic leucine zipper domain containing 1
• NCBI Official Symbol: ASZ1
• NCBI Official Synonym Symbols: ALP1; GASZ; Orf3; ANKL1; C7orf7; CT1.19
• NCBI Protein Information: ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; 4933400N19Rik; ankyrin-like 1; ankyrin-like protein 1; germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein
• UniProt Protein Name: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
• Protein Family: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein
• UniProt Gene Name: ASZ1
• UniProt Synonym Gene Names: ALP1; ANKL1; C7orf7; GASZ
• UniProt Entry Name: ASZ1_HUMAN

Uniprot Description

ASZ1: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: cytoplasm

Molecular Function: signal transducer activity

Biological Process: DNA methylation during gametogenesis; multicellular organismal development; gene expression; RNA-mediated gene silencing; spermatogenesis; male meiosis; cell differentiation; signal transduction