Rabbit ASNA1 Polyclonal Antibody | anti-ASNA1 antibody

ASNA1 Polyclonal Antibody

Cat. Num. AAA2554276

• Gene Names: ASNA1; GET3; ARSA1; TRC40; ARSA-I; ASNA-I
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: ASNA1; Polyclonal Antibody; ASNA1 Polyclonal Antibody; ARSA 1; ARSA; ArsA arsenite transporter ATP binding homolog 1; ArsA arsenite transporter; ATP binding; E. coli; homolog of; 1; ATP-binding; homolog 1 (bacterial); ARSA I; ARSA-I; ARSA1; ARSAI; Arsenical pump driving ATPase; Arsenical pump-driving ATPase; Arsenical resistance ATPase; Arsenite translocating ATPase; Arsenite transporting ATPase; Arsenite-stimulated ATPase; ASNA 1; ASNA I; ASNA-I; ASNA; Asna1 protein; ASNAI; ATPase ASNA1; GET3; Golgi to ER traffic 3 homolog; hARSA-I; hASNA-I; MGC3821; Transmembrane domain recognition complex 40 kDa ATPase subunit; Transmembrane domain recognition complex; 40kDa; TRC40; anti-ASNA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 348

• Applicable Applications for anti-ASNA1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human ASNA1
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using ASNA1 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using ASNA1 antibody.)

Related Product Information for anti-ASNA1 antibody

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.

Product Categories/Family for anti-ASNA1 antibody

Cancer; Cell Biology; Metabolism; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 50428938
• NCBI GeneID: 439
• NCBI Accession #: NP_004308.2
• NCBI GenBank Nucleotide #: NM_004317.3
• UniProt Accession #: O43681; Q53FC6; Q92849; A6NHP8; A8K740
• Molecular Weight: Calculated MW: 38kDa; Observed MW: 39kDa
• NCBI Official Full Name: ATPase ASNA1
• NCBI Official Synonym Full Names: arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
• NCBI Official Symbol: ASNA1
• NCBI Official Synonym Symbols: GET3; ARSA1; TRC40; ARSA-I; ASNA-I
• NCBI Protein Information: ATPase ASNA1
• UniProt Protein Name: ATPase ASNA1
• Protein Family: ATPase
• UniProt Gene Name: ASNA1
• UniProt Synonym Gene Names: ARSA; TRC40

NCBI Description

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Uniprot Description

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (). May be involved in insulin signaling.