Rabbit anti-Human ASCL1 Polyclonal Antibody | anti-ASCL1 antibody

ASCL1 (L68) (Class A Basic Helix-loop-helix Protein 46, Achaete-scute Homolog 1, ASH-1, hASH1, bHLHa46, ASH1, BHLHA46, HASH1)

Cat. Num. AAA626425

• Gene Names: ASCL1; ASH1; HASH1; MASH1; bHLHa46
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: ASCL1; Polyclonal Antibody; ASCL1 (L68) (Class A Basic Helix-loop-helix Protein 46; Achaete-scute Homolog 1; ASH-1; hASH1; bHLHa46; ASH1; BHLHA46; HASH1); Anti -ASCL1 (L68) (Class A Basic Helix-loop-helix Protein 46; anti-ASCL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ASCL1.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ASCL1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:50-1:100
• Immunogen: Synthetic peptide corresponding to amino acid residues surrounding L68 of human ASCL1 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-ASCL1 antibody

Mash1 is a member of the basic helix-loop-helix (BHLH) family of transcription factors. This protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in the gene encoding Mash1 may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Product Categories/Family for anti-ASCL1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 55743094
• NCBI GeneID: 429
• NCBI Accession #: NP_004307.2
• NCBI GenBank Nucleotide #: NM_004316.3
• UniProt Accession #: P50553; Q9BQ30; A8K3C4
• Molecular Weight: 25,454 Da
• NCBI Official Full Name: achaete-scute homolog 1
• NCBI Official Synonym Full Names: achaete-scute complex homolog 1 (Drosophila)
• NCBI Official Symbol: ASCL1
• NCBI Official Synonym Symbols: ASH1; HASH1; MASH1; bHLHa46
• NCBI Protein Information: achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; class A basic helix-loop-helix protein 46
• UniProt Protein Name: Achaete-scute homolog 1
• Protein Family: Achaete-scute
• UniProt Gene Name: ASCL1
• UniProt Synonym Gene Names: ASH1; BHLHA46; HASH1
• UniProt Entry Name: ASCL1_HUMAN

NCBI Description

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq]

Uniprot Description

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cell soma; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity

Biological Process: vestibular nucleus development; response to lithium ion; musculoskeletal movement, spinal reflex action; olfactory pit development; regulation of mitotic cell cycle; cell maturation; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; positive regulation of neuron apoptosis; response to folic acid; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; regulation of timing of subpallium neuron differentiation; positive regulation of cell cycle; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; subpallium neuron fate commitment; commitment of a neuronal cell to a specific type of neuron in the forebrain; regulation of gene expression; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

Disease: Central Hypoventilation Syndrome, Congenital