Rabbit ASCL1 Polyclonal Antibody | anti-ASCL1 antibody

ASCL1 Antibody

Cat. Num. AAA9407435

• Gene Names: ASCL1; ASH1; HASH1; MASH1; bHLHa46
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: ASCL1; Polyclonal Antibody; ASCL1 Antibody; ASH1; HASH1; MASH1; bHLHa46; anti-ASCL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ASCL1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 236

• Applicable Applications for anti-ASCL1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human achaete-scute complex homolog 1 (Drosophila)
• Target Name: ASCL1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/30.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/30.)

Related Product Information for anti-ASCL1 antibody

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Product Categories/Family for anti-ASCL1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 55743094
• NCBI GeneID: 429
• NCBI Accession #: NP_004307.2
• NCBI GenBank Nucleotide #: NM_004316.3
• UniProt Accession #: P50553; Q9BQ30; A8K3C4
• Molecular Weight: 25,454 Da
• NCBI Official Full Name: achaete-scute homolog 1
• NCBI Official Synonym Full Names: achaete-scute family bHLH transcription factor 1
• NCBI Official Symbol: ASCL1
• NCBI Official Synonym Symbols: ASH1; HASH1; MASH1; bHLHa46
• NCBI Protein Information: achaete-scute homolog 1
• UniProt Protein Name: Achaete-scute homolog 1
• Protein Family: Achaete-scute
• UniProt Gene Name: ASCL1
• UniProt Synonym Gene Names: ASH1; BHLHA46; HASH1; ASH-1; hASH1; bHLHa46
• UniProt Entry Name: ASCL1_HUMAN

NCBI Description

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Uniprot Description

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cell soma; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity

Biological Process: vestibular nucleus development; musculoskeletal movement, spinal reflex action; response to lithium ion; regulation of mitotic cell cycle; olfactory pit development; cell maturation; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; response to folic acid; positive regulation of neuron apoptosis; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; positive regulation of cell cycle; regulation of timing of subpallium neuron differentiation; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; regulation of gene expression; commitment of a neuronal cell to a specific type of neuron in the forebrain; subpallium neuron fate commitment; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; negative regulation of apoptosis

Disease: Central Hypoventilation Syndrome, Congenital