Western Blot (WB)
(Western blot analysis ASAH3 using LOVO whole cell lysates)
Rabbit anti-Human ASAH3 Polyclonal Antibody | anti-ASAH3 antibody
ASAH3 Antibody
Western Blot (WB)
(Western blot analysis ASAH3 using LOVO whole cell lysates)
Western Blot (WB)
(Western blot analysis ASAH3 using LOVO whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Uniprot Description
ACER1: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. Belongs to the alkaline ceramidase family.
Protein type: EC 3.5.1.23; Endoplasmic reticulum; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: ceramidase activity
Biological Process: cell differentiation; ceramide catabolic process; epidermis development; keratinocyte differentiation; response to alkalinity; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingosine biosynthetic process
Research Articles on ASAH3
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Product Notes
The ASAH3 acer1 (Catalog #AAA9419154) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASAH3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ASAH3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the ASAH3 acer1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASAH3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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