Rabbit ARTN / Artemin Polyclonal Antibody | anti-ARTN antibody

Rabbit Polyclonal (IgG) to Human ARTN / Artemin

Cat. Num. AAA242810

• Gene Names: ARTN; EVN; NBN; ENOVIN
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ARTN / Artemin; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human ARTN / Artemin; Anti-ARTN / Artemin Antibody (Internal) IHC-plus; ARTN; ENOVIN; EVN; Neurotrophic factor; Artemin; Neublastin; Human ARTN; anti-ARTN antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Internal sequence [GPGSRARAAGARGC] of human Artemin
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 228

• Applicable Applications for anti-ARTN antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human ARTN / Artemin. Percent identity by BLAST analysis: Human, Gorilla (100%); Monkey (93%); Marmoset (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: ARTN / Artemin antibody was raised against synthetic peptide from human ARTN / Artemin. Percent identity by BLAST analysis: Human, Gorilla (100%); Monkey (93%); Marmoset (86%).
• Antigen Modification: Internal
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ARTN / Artemin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-ARTN / Artemin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Product Categories/Family for anti-ARTN antibody

Family: TGF beta

NCBI and Uniprot Product Information

• NCBI GI #: 209954776
• NCBI GeneID: 9048
• NCBI Accession #: NP_003967.2
• NCBI GenBank Nucleotide #: NM_003976.3
• UniProt Accession #: Q5T4W7; O95441; O96030; Q6P6A3; D3DPY1; D3DPY3
• Molecular Weight: 23,616 Da
• NCBI Official Synonym Full Names: artemin
• NCBI Official Symbol: ARTN
• NCBI Official Synonym Symbols: EVN; NBN; ENOVIN
• NCBI Protein Information: artemin
• UniProt Protein Name: Artemin
• UniProt Gene Name: ARTN
• UniProt Synonym Gene Names: EVN
• UniProt Entry Name: ARTN_HUMAN

NCBI Description

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Description

artemin: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Belongs to the TGF-beta family. GDNF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; receptor binding

Biological Process: axon guidance; neuroblast proliferation; signal transduction; induction of positive chemotaxis; peripheral nervous system development