Western Blot (WB)
(Western blot analysis of ARR3 in EL4 cell lysate with ARR3 antibody at (A) 0.5 and (B) 1 μg/ml.)
Rabbit ARR3 Polyclonal Antibody | anti-ARR3 antibody
ARR3 Antibody
Gene Names
ARR3; ARRX
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
ARR3 antibody is affinity chromatography purified via peptide column.
Synonyms
ARR3; Polyclonal Antibody; ARR3 Antibody; ARRX; CAR; Arrestin-C; Cone arrestin; C-arrestin; arrestin 3; retinal (X-arrestin); anti-ARR3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
ARR3 antibody is human, mouse and rat reactive. At least three isoforms of ARR3 are known to exist. This antibody is predicted to not cross-react with other members of the arrestin protein family.
Purity/Purification
ARR3 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
388
Applicable Applications for anti-ARR3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ARR3 antibody can be used for detection of ARR3 by Western blot at 0.5 - 1 mug/ml.
Conjugate
Unconjugated
Immunogen
ARR3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ARR3.
Buffer
ARR3 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ARR3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(Western blot analysis of ARR3 in EL4 cell lysate with ARR3 antibody at (A) 0.5 and (B) 1 μg/ml.)
Western Blot (WB)
(Western blot analysis of ARR3 in EL4 cell lysate with ARR3 antibody at (A) 0.5 and (B) 1 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ARR3 in mouse spleen tissue with ARR3 antibody at 2 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ARR3 in mouse spleen tissue with ARR3 antibody at 2 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of ARR3 in mouse spleen tissue with ARR3 antibody at 20 μg/ml.Green: ARR3 Antibody (7643)Blue: DAPI staining)
Immunofluorescence (IF)
(Immunofluorescence of ARR3 in mouse spleen tissue with ARR3 antibody at 20 μg/ml.Green: ARR3 Antibody (7643)Blue: DAPI staining)
Related Product Information for anti-ARR3 antibody
Arrestin 3 (ARR3) belongs to the Arrestin family of proteins that function as negative regulators of G protein-coupled receptor (GPCR) signaling (1,2). ARR3 binds the c-Jun N-terminal kinase 3 (JNK3) and scaffolds the apoptosis signal-regulating kinase 1 (ASK1)-MAPK kinase4-JNK3 cascade in a receptor-independent fashion, promoting JNK3 phosphorylation (3,4). ARR3 also mediates the internalization of the C-C chemokine receptor CCR7 upon the binding of its ligand CCL19, but not CCL21, suggesting that it helps mediate CCR7 receptor desensitization (5).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 43 kDa
Observed: 47 kDa
Observed: 47 kDa
NCBI Official Full Name
arrestin-C
NCBI Official Synonym Full Names
arrestin 3, retinal (X-arrestin)
NCBI Official Symbol
ARR3
NCBI Official Synonym Symbols
ARRX
NCBI Protein Information
arrestin-C; cArr; C-arrestin; X-arrestin; arrestin 4; cone arrestin; retinal cone arrestin-3
UniProt Protein Name
Arrestin-C
Protein Family
UniProt Gene Name
ARR3
UniProt Synonym Gene Names
ARRX; CAR; C-arrestin; cArr
UniProt Entry Name
ARRC_HUMAN
Uniprot Description
ARR3: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. Belongs to the arrestin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xcen-q21
Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cytoplasm; synapse
Molecular Function: protein binding; opsin binding; phosphoprotein binding
Biological Process: regulation of protein amino acid phosphorylation; visual perception; endocytosis; signal transduction
Research Articles on ARR3
Similar Products
Product Notes
The ARR3 arr3 (Catalog #AAA153382) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARR3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ARR3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ARR3 antibody can be used for detection of ARR3 by Western blot at 0.5 - 1 mug/ml. Researchers should empirically determine the suitability of the ARR3 arr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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