Testing Data
Rabbit ARNTL Polyclonal Antibody | anti-ARNTL antibody
ARNTL Antibody
IP: 1:200-1:1000
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Description
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: transcription factor complex; PML body; nucleus
Molecular Function: protein binding; signal transducer activity; DNA binding; aryl hydrocarbon receptor binding; protein heterodimerization activity; sequence-specific DNA binding; bHLH transcription factor binding; Hsp90 protein binding
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; regulation of cell cycle; positive regulation of transcription, DNA-dependent; response to redox state; positive regulation of circadian rhythm; signal transduction; negative regulation of fat cell differentiation; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; regulation of protein catabolic process; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of insulin secretion
Research Articles on ARNTL
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Product Notes
The ARNTL arntl (Catalog #AAA2521460) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARNTL Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ARNTL can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP). WB: 1:200-1:2000 IP: 1:200-1:1000. Researchers should empirically determine the suitability of the ARNTL arntl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARNTL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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