Western Blot (WB)
(ARL1 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the ARL1 antibody detected the ARL1 protein (arrow).)
Rabbit ARL1 Polyclonal Antibody | anti-ARL1 antibody
ARL1 Antibody (Center)
Western Blot (WB)
(ARL1 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the ARL1 antibody detected the ARL1 protein (arrow).)
Western Blot (WB)
(ARL1 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the ARL1 antibody detected the ARL1 protein (arrow).)
(ADP-ribosylation factor-like) family of proteins, which are
structurally related to ADP-ribosylation factors (ARFs). ARFs,
described as activators of cholera toxin (CT)
ADP-ribosyltransferase activity, regulate intracellular vesicular
membrane trafficking, and stimulate a phospholipase D (PLD)
isoform. Although, ARL proteins were initially thought not to
activate CT or PLD, later work showed that they are weak
stimulators of PLD and CT in a phospholipid dependent manner.
Nishimoto-Morita, K., et al. J. Biol. Chem. 284(16):10583-10592(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Zahn, C., et al. Mol. Membr. Biol. 23(6):475-485(2006)
Lu, L., et al. Mol. Biol. Cell 15(10):4426-4443(2004)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Uniprot Description
ARL1: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: Golgi membrane; Golgi apparatus; cytoplasm; trans-Golgi network
Molecular Function: GTPase activity; protein domain specific binding; GTP binding; metal ion binding; enzyme activator activity
Biological Process: phospholipase D activation; small GTPase mediated signal transduction; protein localization in Golgi apparatus; toxin metabolic process; retrograde transport, endosome to Golgi; Golgi organization and biogenesis; Golgi vesicle transport
Research Articles on ARL1
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Product Notes
The ARL1 arl1 (Catalog #AAA9210271) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 81-108. The ARL1 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ARL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ARL1 arl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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