Rabbit anti-Human ARID2 Polyclonal Antibody | anti-ARID2 antibody

ARID2 Polyclonal Antibody

Cat. Num. AAA3009273

• Gene Names: ARID2; CSS6; p200; BAF200
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ARID2; Polyclonal Antibody; ARID2 Polyclonal Antibody; AT-rich interactive domain-containing protein 2; ARID domain-containing protein 2; BRG1-associated factor 200; BAF200; Zinc finger protein with activation potential; Zipzap/p200; KIAA1557; anti-ARID2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ARID2 polyclonal antibody detects endogenous levels of ARID2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1788

• Applicable Applications for anti-ARID2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human ARID2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of ARID2 antibody.)

Western Blot (WB)

(Western Blot analysis of extracts from normal (control) and ARID2 knockout (KO) HeLa cells, using ARID2 antibody.)

Related Product Information for anti-ARID2 antibody

ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]

NCBI and Uniprot Product Information

• NCBI GI #: 1115538452
• NCBI GeneID: 196528
• NCBI Accession #: NP_001334768.1
• NCBI GenBank Nucleotide #: NP_001334768.1
• UniProt Accession #: Q68CP9
• Molecular Weight: ~ 250kDa
• NCBI Official Full Name: AT-rich interactive domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: AT-rich interaction domain 2
• NCBI Official Symbol: ARID2
• NCBI Official Synonym Symbols: CSS6; p200; BAF200
• NCBI Protein Information: AT-rich interactive domain-containing protein 2
• UniProt Protein Name: AT-rich interactive domain-containing protein 2
• Protein Family: AT-rich interactive domain-containing protein
• UniProt Gene Name: ARID2
• UniProt Synonym Gene Names: KIAA1557; ARID domain-containing protein 2; BAF200

NCBI Description

This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016]

Uniprot Description

ARID2: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: nucleoplasm; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of cell migration; negative regulation of cell proliferation; nucleosome disassembly