Western Blot (WB)
(Western blot analysis of human ARHGEF11 in rat brain lysate in the 1) absence and 2) presence of immunizing peptide using MBS6010365 at 0.1ug/ml.)
Rabbit ARHGEF11 Polyclonal Antibody | anti-Arhgef11 antibody
ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11, PDZ-RhoGEF, KIAA0380)
Gene Names
Arhgef11; Prg; RhoGEF; mKIAA0380; B930073M02; E130307F09; PDZ-RhoGEF
Reactivity
Bovine, Human, Monkey, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
ARHGEF11; Polyclonal Antibody; ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11; PDZ-RhoGEF; KIAA0380); Anti -ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11; anti-Arhgef11 antibody
Host
Rabbit
Reactivity
Bovine, Human, Monkey, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human ARHGEF11. Species Crossreactivity
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Applicable Applications for anti-Arhgef11 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.1-0.5ug/ml
Immunohistochemistry (paraffin): 10ug/ml
Dilution: Western Blot: 0.1-0.5ug/ml
Immunohistochemistry (paraffin): 10ug/ml
Immunogen
Synthetic peptide corresponding to aa1-50 of human ARHGEF11.
Positive Control
Rat brain lysate
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(Western blot analysis of human ARHGEF11 in rat brain lysate in the 1) absence and 2) presence of immunizing peptide using MBS6010365 at 0.1ug/ml.)
Western Blot (WB)
(Western blot analysis of human ARHGEF11 in rat brain lysate in the 1) absence and 2) presence of immunizing peptide using MBS6010365 at 0.1ug/ml.)
Immunohistochemistry (IHC)
(IHC analysis of human skin using MBS6010365 at 10ug/ml.)
Immunohistochemistry (IHC)
(IHC analysis of human skin using MBS6010365 at 10ug/ml.)
Related Product Information for anti-Arhgef11 antibody
ARHGEF11 is a 1527aa protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
Product Categories/Family for anti-Arhgef11 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Arhgef11 protein, partial
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 11
NCBI Official Symbol
Arhgef11
NCBI Official Synonym Symbols
Prg; RhoGEF; mKIAA0380; B930073M02; E130307F09; PDZ-RhoGEF
NCBI Protein Information
rho guanine nucleotide exchange factor 11
Protein Family
Research Articles on Arhgef11
Similar Products
Product Notes
The Arhgef11 (Catalog #AAA6010365) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11, PDZ-RhoGEF, KIAA0380) reacts with Bovine, Human, Monkey, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ARHGEF11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 0.1-0.5ug/ml Immunohistochemistry (paraffin): 10ug/ml. Researchers should empirically determine the suitability of the Arhgef11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARHGEF11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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