Rabbit anti-Human ARA9 Polyclonal Antibody | anti-AIP antibody

Anti-ARA9 Antibody

Cat. Num. AAA176770

• Gene Names: AIP; ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: ARA9; Polyclonal Antibody; Anti-ARA9 Antibody; AH receptor-interacting protein; aryl hydrocarbon receptor interacting protein; AH receptor interacting protein antibody; AH receptor-interacting protein antibody; AIP antibody; AIP_HUMAN antibody; ARA 9 antibody; Aryl hydrocarbon receptor interacting protein antibody; Aryl-hydrocarbon receptor-interacting protein antibody; fa03h10 antibody; FKBP 16 antibody; FKBP 37 antibody; FKBP16 antibody; FKBP37 antibody; HBV X associated protein 2 antibody; HBV X associated protein antibody; HBV X-associated protein 2 antibody; HBVX associated protein antibody; Immunophilin homolog ARA 9 antibody; Immunophilin homolog ARA9 antibody; SMTPHN antibody; XAP 2 antibody; XAP-2 antibody; XAP2 antibody; anti-AIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 330

• Applicable Applications for anti-AIP antibody: Western Blot (WB)
• Immunogen: E Coli-derived human ARA9 recombinant protein (Position: D91-H330). Human ARA9 shares 95% amino acid (aa) sequences identity with both mouse and rat ARA9.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Testing Data

(Anti-ARA9 Picoband antibody, MBS176770-1.jpgAll lanes: Anti-ARA9(MBS176770) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: COLO320 Whole Cell Lysate at 40ugLane 3: HT1080 Whole Cell Lysate at 40ugLane 4: MCF-7 Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugLane 6: U87 Whole Cell Lysate at 40ugLane 7: MM231 Whole Cell Lysate at 40ugPredicted bind size: 38KDObserved bind size: 38KD )

Related Product Information for anti-AIP antibody

Description: Rabbit IgG polyclonal antibody for AH receptor-interacting protein(AIP) detection. Tested with WB in Human.
Background: AIP, also known as, ARA9 or XAP-2, is a protein that in humans is encoded by the AIP gene. This gene is mapped to 11q13.2. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. It has been shown that AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein. AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA).

NCBI and Uniprot Product Information

• NCBI GI #: 254763247
• NCBI GeneID: 9049
• UniProt Accession #: O00170; Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6
• Molecular Weight: 37,636 Da
• NCBI Official Full Name: AH receptor-interacting protein
• NCBI Official Synonym Full Names: aryl hydrocarbon receptor interacting protein
• NCBI Official Symbol: AIP
• NCBI Official Synonym Symbols: ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• NCBI Protein Information: AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
• UniProt Protein Name: AH receptor-interacting protein
• Protein Family: AH receptor-interacting protein
• UniProt Gene Name: AIP
• UniProt Synonym Gene Names: XAP2; AIP; XAP-2
• UniProt Entry Name: AIP_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]

Uniprot Description

AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; signal transducer activity; transcription coactivator activity; unfolded protein binding; transcription factor binding

Biological Process: protein maturation via protein folding; xenobiotic metabolic process; signal transduction; protein targeting to mitochondrion; negative regulation of cyclic-nucleotide phosphodiesterase activity

Disease: Pituitary Adenoma, Prolactin-secreting; Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting