Rabbit anti-Human Aquaporin, Adipose Specific Polyclonal Antibody | anti-Aqp7 antibody

Aquaporin, Adipose Specific (AQPAP, AQP7-Like)

Cat. Num. AAA613903

• Gene Names: Aqp7; AQP7L; AQPap
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Aquaporin; Adipose Specific; Polyclonal Antibody; Adipose Specific (AQPAP; AQP7-Like); Anti -Aquaporin; anti-Aqp7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Aquaporin, adipose specific. Species sequence homology: chimp and monkey, 100%.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-Aqp7 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot:1:1000-1:5000; ELISA: 1:100,000. 50-100ng/well of A3002-20 can be used to coat ELISA plates
• Immunogen: Synthetic peptide corresponding to 20aa sequence within the N-terminal, cytoplasmic domain of human Aquaporin, adipose specific (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Aqp7 antibody

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. AQP0 or MIP26 (major intrinsic protein 26kD), and Aquaporin-1 (AQP1, purified from red cells) also called CHIP-28 (channel forming integral protein, 28kD; 268aa; gene locus 7p14) has been the foundation of the growing family of aquaporin. The lens specific AQP0 represents up to 80% of total lens membrane protein. Defects in MIP26 are cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an amino acid substitution that inhibits targeting of MIP to the cell membrane. Most recently, adipose specific AQP-adipose (342aa; AQPAP or AQP7-like) has been cloned. It facilities water and glycerol transport. AQP families of proteins are predicted to contain six transmembrane domains. The N- and C-terminus are predicted to be cytoplasmic.

Product Categories/Family for anti-Aqp7 antibody

Antibodies; Abs to Aquaporin

NCBI and Uniprot Product Information

• NCBI GI #: 15787883
• NCBI GeneID: 11832
• UniProt Accession #: O54794; Q8C630; Q5DX24
• Molecular Weight: 32,667 Da
• NCBI Official Full Name: aquaporin adipose
• NCBI Official Synonym Full Names: aquaporin 7
• NCBI Official Symbol: Aqp7
• NCBI Official Synonym Symbols: AQP7L; AQPap
• NCBI Protein Information: aquaporin-7; AQP-7; OTTMUSP00000006986; OTTMUSP00000006987; aquaglyceroporin-7
• UniProt Protein Name: Aquaporin-7
• Protein Family: Aquaporin
• UniProt Gene Name: Aqp7
• UniProt Entry Name: AQP7_MOUSE

Uniprot Description

AQP7: Forms a channel for water and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, aquaporin family

Cellular Component: membrane; brush border membrane; cell; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intercellular junction; ribonucleoprotein complex

Molecular Function: urea channel activity; transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity

Biological Process: glycerol transport; cellular water homeostasis; transport; urea transport; water transport; cellular response to stress; transmembrane transport