Rabbit anti-Human Aquaporin 10 Polyclonal Antibody | anti-AQP10 antibody

Aquaporin 10 (AQP10)

Cat. Num. AAA612732

• Gene Names: AQP10; AQPA_HUMAN
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Aquaporin 10; Polyclonal Antibody; Aquaporin 10 (AQP10); Anti -Aquaporin 10 (AQP10); anti-AQP10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Aquaporin 10. The 17aa peptide is unique to AQP10 without significant homology to any other AQPs.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 40% glycerol.

• Applicable Applications for anti-AQP10 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:10,000-1:50,000; Control peptide (A3000-70) can be used to coat ELISA plates at 1ug/ml.; Western Blot: 1:1000-1:5000
• Immunogen: A 17aa synthetic peptide within the cytoplasmic, C-terminal region of human AQP10 coupled to KLH
• Note: We recommend the use of 0.5-1% milk in all primary/secondary antibody-enzyme conjugate incubations in order to suppress non-specific bands.; Optimal dilutions to be determined by the researcher.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-AQP10 antibody

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. A new member of AQP family, AQP10, has been cloned (1). AQP10 (human 264aa) is most closely related with AQP3 (53%), AQP9 (52%), and AQP7 (43%). It is abundantly expressed in duodenum and jejunum. AQP10 is not permeable to urea and glycerol.

Product Categories/Family for anti-AQP10 antibody

Antibodies; Abs to Aquaporin

NCBI and Uniprot Product Information

• NCBI GI #: 51513342
• NCBI GeneID: 89872
• UniProt Accession #: Q96PS8; Q5VYD3; Q5VYD4; Q8NG70
• Molecular Weight: 31,763 Da
• NCBI Official Full Name: Aquaporin 10
• NCBI Official Synonym Full Names: aquaporin 10
• NCBI Official Symbol: AQP10
• NCBI Official Synonym Symbols: AQPA_HUMAN
• NCBI Protein Information: aquaporin-10; AQP-10; OTTHUMP00000034195; OTTHUMP00000034196; aquaglyceroporin-10; small intestine aquaporin
• UniProt Protein Name: Aquaporin-10
• Protein Family: Aquaporin
• UniProt Gene Name: AQP10
• UniProt Entry Name: AQP10_HUMAN

NCBI Description

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq]

Uniprot Description

AQP10: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, aquaporin family; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: urea transmembrane transporter activity; water channel activity; glycerol channel activity

Biological Process: glycerol transport; cellular water homeostasis; water transport; response to toxin; transmembrane transport