Western Blot (WB)
(Western blotAll lanes: TP53BP2 antibody at 2ug/ml+mouse thymusSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 126,112,127 kDaObserved band size: 126 kDa)
Rabbit anti-Human, Mouse Apoptosis-stimulating of p53 protein 2 Polyclonal Antibody | anti-TP53BP2 antibody
Rabbit anti-human Apoptosis-stimulating of p53 protein 2 polyclonal Antibody(TP53BP2)
Western Blot (WB)
(Western blotAll lanes: TP53BP2 antibody at 2ug/ml+mouse thymusSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 126,112,127 kDaObserved band size: 126 kDa)
Western Blot (WB)
(Western blotAll lanes: TP53BP2 antibody at 2ug/ml+mouse thymusSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 126,112,127 kDaObserved band size: 126 kDa)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process: cell cycle; central nervous system development; embryonic development ending in birth or egg hatching; heart development; negative regulation of cell cycle; positive regulation of signal transduction; response to ionizing radiation; signal transduction
Research Articles on TP53BP2
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Product Notes
The TP53BP2 tp53bp2 (Catalog #AAA1494228) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Apoptosis-stimulating of p53 protein 2 polyclonal Antibody(TP53BP2) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Apoptosis-stimulating of p53 protein 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Recommended dilution: WB:1:200-1000. Researchers should empirically determine the suitability of the TP53BP2 tp53bp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Apoptosis-stimulating of p53 protein 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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