Rabbit Apolipoprotein CIII (Apo CIII) Polyclonal Antibody | anti-APOC3 antibody

Rabbit anti Human Apo CIII

Cat. Num. AAA316057

• Gene Names: APOC3; APOCIII; MGC150353
• Applications: ELISA, Western Blot
• Purity: Human Apo CIII-Sepharose affinity column
• Synonyms: Apolipoprotein CIII (Apo CIII); Polyclonal Antibody; Rabbit anti Human Apo CIII; Rabbit Antibody to Human Apolipoprotein CIII (Apo CIII); anti-APOC3 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Apolipoprotein CIII (Apo CIII); Specifically binds to human Apo CIII.
• Purity/Purification: Human Apo CIII-Sepharose affinity column
• Form/Format: Affinity Purified, Liquid
• Concentration: 1mg/ml (OD280nm, E^0.1% = 1.35) (varies by lot)
• Sequence Length: 99

• Applicable Applications for anti-APOC3 antibody: EIA/ELISA, Western Blot
• Application Notes: Can be used to detect the existence of Apo CIII in plasma and lipoproteins; for immunoassay, immunoblot, enzyme conjugation or biotinylation. Dilution range for immunoblot and ELISA: 1:5,000 to 1:40,000. Each laboratory should determine an optimum working
• Immunogen: Human Apolipoprotein CIII
• Buffer: 75mM PBS, 75mM Sodium chloride containing 0.5mM EDTA, pH 7.2
• Preservative: 0.02% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Short-term store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.

Product Categories/Family for anti-APOC3 antibody

Polyclonal Antibodies to Lipoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 4557323
• NCBI GeneID: 345
• NCBI Accession #: NP_000031.1
• NCBI GenBank Nucleotide #: NM_000040.1
• UniProt Accession #: P02656; Q08E83; Q6Q786
• Molecular Weight: 10,852 Da
• NCBI Official Full Name: apolipoprotein C-III
• NCBI Official Synonym Full Names: apolipoprotein C-III
• NCBI Official Symbol: APOC3
• NCBI Official Synonym Symbols: APOCIII; MGC150353
• NCBI Protein Information: apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353
• UniProt Protein Name: Apolipoprotein C-III
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOC3
• UniProt Entry Name: APOC3_HUMAN

NCBI Description

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]

Uniprot Description

Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10

Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [

MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11

Sequence similarities: Belongs to the apolipoprotein C3 family.